A0KT85 · ISPE_SHESA

  • Protein
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • Gene
    ispE
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for active site, binding site.

128420406080100120140160180200220240260280
TypeIDPosition(s)Description
Active site14
Binding site98-108ATP (UniProtKB | ChEBI)
Active site140

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Gene names

    • Name
      ispE
    • Ordered locus names
      Shewana3_0766

Organism names

Accessions

  • Primary accession
    A0KT85

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000078911-2844-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    30,766
  • Last updated
    2006-12-12 v1
  • Checksum
    CD601944B01FF197
MSNEISRNWPAPAKLNLFLHINGRRADGYHELQTLFQFIDCCDQLDFRVTQTPELILHSNMSAVVADSDNLILRAAKSLQQATSYPGGAEIWLEKRLPMGGGLGGGSSDAATTLVALNQLWNTQLSNDELAAIGLKLGADIPVFIRGFAAFAEGVGERLQAVTPTEFWYLVIAPDAHVSTAAVFQDPLLPRNTPKLGIDTLMSQPWANDCQDLVVSKYPQVAKALGWLLEYAPSRMTGTGACVFGEFSSQQQALAALAKLPSDMQGFVAKGMNISPLIVRLTHP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000469
EMBL· GenBank· DDBJ
ABK47004.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp