A0KK76 · FADI_AERHH
- Protein3-ketoacyl-CoA thiolase
- GenefadI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids436 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Catalytic activity
- an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 99 | Acyl-thioester intermediate | |||
Active site | 392 | Proton acceptor | |||
Active site | 422 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | acetyl-CoA C-acyltransferase activity | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-ketoacyl-CoA thiolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas
Accessions
- Primary accessionA0KK76
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000069492 | 1-436 | 3-ketoacyl-CoA thiolase | ||
Interaction
Subunit
Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length436
- Mass (Da)46,427
- Last updated2006-12-12 v1
- MD5 ChecksumE9380B587AB23AD6F65E75500D5672E8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000462 EMBL· GenBank· DDBJ | ABK38830.1 EMBL· GenBank· DDBJ | Genomic DNA |