A0KF11 · BIOH_AERHH

Function

function

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

Pathway

Cofactor biosynthesis; biotin biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site20substrate
Active site82Nucleophile
Binding site82-83substrate
Binding site143-147substrate
Active site207
Active site235
Binding site235substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarboxylic ester hydrolase activity
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Pimeloyl-[acyl-carrier protein] methyl ester esterase
  • EC number
  • Alternative names
    • Biotin synthesis protein BioH
    • Carboxylesterase BioH

Gene names

    • Name
      bioH
    • Ordered locus names
      AHA_0299

Organism names

Accessions

  • Primary accession
    A0KF11

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002141221-254Pimeloyl-[acyl-carrier protein] methyl ester esterase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-242AB hydrolase-1

Sequence similarities

Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    254
  • Mass (Da)
    27,945
  • Last updated
    2006-12-12 v1
  • Checksum
    3B91FFC7D1D7A603
MSVSVERFGQGPDLVLLHGWGMNGAVWHGIVPALASRYRVHLVDLPGFGNSPLAGEVEYSLPWLAEEVAAILPEQCHLLGWSLGGLVASQLALSHPERLHSLITVASSPCFMARDEWPGIAPKVLAGFNQMLAGDFKQTIERFLAIQAMGSEHARDDIRQLRHWLAERPAPQLAALEAGLGLLAEVDLRDELTPLSLPWLRVYGRLDSLVPKASIPLLDERYPSSRSVVLEKASHAPFISHPQQFIEIIEHFVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000462
EMBL· GenBank· DDBJ
ABK36065.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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