A0KEX7 · HEM6_AERHH
- ProteinOxygen-dependent coproporphyrinogen-III oxidase
- GenehemF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Catalytic activity
- coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX
Cofactor
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 94 | substrate | ||||
Sequence: S | ||||||
Binding site | 98 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 108 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 108 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 110-112 | substrate | ||||
Sequence: NVR | ||||||
Binding site | 147 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 177 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 177 | Important for dimerization | ||||
Sequence: H | ||||||
Binding site | 260-262 | substrate | ||||
Sequence: GGR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | coproporphyrinogen oxidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxygen-dependent coproporphyrinogen-III oxidase
- EC number
- Short namesCPO ; Coprogen oxidase ; Coproporphyrinogenase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas
Accessions
- Primary accessionA0KEX7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000019455 | 1-302 | Oxygen-dependent coproporphyrinogen-III oxidase | |||
Sequence: MSKPDVAQVKAFLLQLQDEICRGLELADGAGHFVEDAWRREGGGGGRTRVLRHGAVIEQGGVNFSHVHGDAMPASATAHRPELAGRRFEAMGVSLVIHPHNPYVPTSHANVRFFIAEKEGEEPIWWFGGGFDLTPFYPFEEDVRHWHQLSRDLCQPFGTDIYPEFKSWCDRYFFLKHRDETRGVGGLFFDDLNRWPFADCFAFMQAVGKGYLDAYLPIVERRKALAYGEREREFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLARWEYDWQPSAGSPEALLYSDYLKPREWL |
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 242-277 | Important for dimerization | ||||
Sequence: YVEFNLVYDRGTLFGLQTGGRTESILMSMPPLARWE |
Sequence similarities
Belongs to the aerobic coproporphyrinogen-III oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)34,778
- Last updated2006-12-12 v1
- ChecksumE81F1C39BE849E30
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000462 EMBL· GenBank· DDBJ | ABK36850.1 EMBL· GenBank· DDBJ | Genomic DNA |