A0K4Z6 · HGD_BURCH
- ProteinHomogentisate 1,2-dioxygenase
- GenehmgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids444 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
Catalytic activity
- homogentisate + O2 = 4-maleylacetoacetate + H+
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 298 | Proton acceptor | |||
Binding site | 341 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 347 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 356 | homogentisate (UniProtKB | ChEBI) | |||
Binding site | 377 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 377 | homogentisate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homogentisate 1,2-dioxygenase activity | |
Molecular Function | iron ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomogentisate 1,2-dioxygenase
- EC number
- Short namesHGDO
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0K4Z6
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000019522 | 1-444 | Homogentisate 1,2-dioxygenase | ||
Interaction
Subunit
Hexamer; dimer of trimers.
Structure
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)48,960
- Last updated2006-12-12 v1
- MD5 Checksum79C53AC6762E0920CD9716811BBECBED
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000458 EMBL· GenBank· DDBJ | ABK07573.1 EMBL· GenBank· DDBJ | Genomic DNA |