A0K4Z6 · HGD_BURCH

Function

function

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site298Proton acceptor
Binding site341Fe cation (UniProtKB | ChEBI)
Binding site347Fe cation (UniProtKB | ChEBI)
Binding site356homogentisate (UniProtKB | ChEBI)
Binding site377Fe cation (UniProtKB | ChEBI)
Binding site377homogentisate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhomogentisate 1,2-dioxygenase activity
Molecular Functioniron ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homogentisate 1,2-dioxygenase
  • EC number
  • Short names
    HGDO
  • Alternative names
    • Homogentisate oxygenase
    • Homogentisic acid oxidase
    • Homogentisicase

Gene names

    • Name
      hmgA
    • Ordered locus names
      Bcen2424_0820

Organism names

Accessions

  • Primary accession
    A0K4Z6

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000195221-444Homogentisate 1,2-dioxygenase

Interaction

Subunit

Hexamer; dimer of trimers.

Structure

Family & Domains

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    444
  • Mass (Da)
    48,960
  • Last updated
    2006-12-12 v1
  • MD5 Checksum
    79C53AC6762E0920CD9716811BBECBED
MTLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEPYAGAQRLVSEFGDSADVPPTPPNQLRWDPLPMPVEPTDFVDGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGELLIVPQQGRLFIATEFGRLDVEPFEIAVIPRGVRFAVALPDGNARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQAAYEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLQAQSDTPGVDTIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDATMAFMFETRTLIRPTRYALDTAQLQADYFECWQGIKKHFNPEQR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000458
EMBL· GenBank· DDBJ
ABK07573.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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