RHAU deletion in hematopoietic system caused hemolytic anemia and differentiation defect at the proerythroblast stage. RHAU may play a role in the regulation of gene expression that relies on its G4 resolvase activity.
DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TRIF pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells
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