A0CIN9 · A0CIN9_PARTE

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      GSPATT00007791001

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Stock d4-2
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Peniculida > Parameciidae > Paramecium

Accessions

  • Primary accession
    A0CIN9

Proteomes

    • Identifier
    • Component
      Partially assembled WGS sequence

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane74-94Helical
Transmembrane101-121Helical
Transmembrane192-216Helical
Transmembrane299-317Helical
Transmembrane337-353Helical
Transmembrane365-385Helical
Transmembrane391-412Helical
Transmembrane424-450Helical
Transmembrane470-491Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-494Major facilitator superfamily (MFS) profile
Region233-282Disordered

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    539
  • Mass (Da)
    60,801
  • Last updated
    2006-11-28 v1
  • Checksum
    D5EFC838802645C3
MLRSSSFLGGYSRSLSKNKLRPRVLSYRHTKLRYLALFFACMIMIGDAYCFDNPMALQSEIKDKYEVDQFKFNLLYTVYSLPNIILPFFGGVLIDKIGARTAILLFSSIIMIGQLVCVWGASNLSYWTLITGRVIFGMGSESLNVSQNSIMAIWFKDQEMSLAIGLCISIPKIGNALNSLLSPQIYSKYQSLAAPMMVGVGTLIFSFICGIALIYMDYKSEQREKQNQMLLNKNDENHRSQSELSASVKQSVKDEDCDSPDLGRSPEIFATPQHHEEPEEHEAKEEINFKDIAKLSGTFWILIIICMLTEALFVPFLDNGNELLQERFGMTAEQAGLFLIIPYLVASGSTPFIGNMADKFGRRSLLIIVTSFIFLITHILFIFRMCTSACFLITLPLTILGLCFGFYASVVIPSVPFVVKSNLVGTAFGLTGVFQNTALALFPMITGMIFNQFKYDEHGEENEERGYVYQSFFFIGMSVLLVIIAILLMFVDKNGERKLSQKGRGIPKKNKVDYLSVHEVTDIPEDKKIRIDYDTDHRI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CT868085
EMBL· GenBank· DDBJ
CAK70656.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help