A0BZ55 · ASNA1_PARTE
- ProteinATPase ASNA1 homolog 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids329 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 26-33 | ATP (UniProtKB | ChEBI) | |||
Active site | 55 | ||||
Binding site | 235 | ATP (UniProtKB | ChEBI) | |||
Binding site | 262 | ATP (UniProtKB | ChEBI) | |||
Binding site | 271 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 274 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | GET complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | metal ion binding | |
Biological Process | tail-anchored membrane protein insertion into ER membrane |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATPase ASNA1 homolog 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Peniculida > Parameciidae > Paramecium
Accessions
- Primary accessionA0BZ55
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000388167 | 1-329 | ATPase ASNA1 homolog 1 | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length329
- Mass (Da)37,328
- Last updated2006-11-28 v1
- Checksum56E0D3AE267C148C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CT868028 EMBL· GenBank· DDBJ | CAK63822.1 EMBL· GenBank· DDBJ | Genomic DNA |