A0BZ55 · ASNA1_PARTE

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Features

Showing features for binding site, active site.

132950100150200250300
Type
IDPosition(s)Description
Binding site26-33ATP (UniProtKB | ChEBI)
Active site55
Binding site235ATP (UniProtKB | ChEBI)
Binding site262ATP (UniProtKB | ChEBI)
Binding site271Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site274Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmetal ion binding
Biological Processtail-anchored membrane protein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog 1
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog 1
    • Arsenite-stimulated ATPase 1

Gene names

    • ORF names
      GSPATT00033675001

Organism names

  • Taxonomic identifier
  • Strain
    • Stock d4-2
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Peniculida > Parameciidae > Paramecium

Accessions

  • Primary accession
    A0BZ55

Proteomes

    • Identifier
    • Component
      Partially assembled WGS sequence

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003881671-329ATPase ASNA1 homolog 1

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the arsA ATPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    37,328
  • Last updated
    2006-11-28 v1
  • Checksum
    56E0D3AE267C148C
MQQQVEPTLKNVLENQTLKWIFVGGKGGVGKTTTSSSLATLFAKSGKRTIIISTDPAHNLSDCFDQKIGSQPTQIKGIENLSAMEIDPTVDPDKLKLPTLQGFMNDQATKSLLSELISSVPGIDEAMSFAELMNSVDEMKYDLIIFDTAPTGHTLRLLNFPNIMEKGLNKLVQLRYNFQNLASQFQGLFGSQEEFDQQMNQMFSKIETMKDTVTKVNAQMKDRNKTTFIGVCIPEFLSMYETERLVQELTKFKIDIHNIVINQVLFPDDQCKMCNARAKMQKKYLDQMIDLYDDFHVVIMPLQENEVRGIDGLKQFCELLLKPKSVPQF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CT868028
EMBL· GenBank· DDBJ
CAK63822.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help