A0AAX0HUP7 · A0AAX0HUP7_XANCG

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      BIY41_05475

Organism names

Accessions

  • Primary accession
    A0AAX0HUP7

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain48-272Mur ligase central
Domain296-418Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    45,388
  • Last updated
    2024-11-27 v1
  • MD5 Checksum
    F32DC16DC421830827F9700F0D8F3BE0
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAFIEAIGRAAGWKVGAYTSPHLLRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVITTVDLDHTDWLGDDREAIGAEKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPHWHWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQRLEVDGVQVLLDVGHNPQAARALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDRWALAGLEGARGQSAQALQARLQGSAAAQALCHRDVASAVRAVLDAASPGDRVLVFGSFHTVADALGALRSAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MKCQ01000023
EMBL· GenBank· DDBJ
OEY88167.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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