A0AAX0HUP7 · A0AAX0HUP7_XANCG
- ProteinDihydrofolate synthase/folylpolyglutamate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids432 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Catalytic activity
- (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H+
(6R)-5,10-methylenetetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:13257
+ CHEBI:29985 + CHEBI:30616 = (6R)-5,10-methylenetetrahydrofolyl-(γ-L-Glu)(n+1) RHEA-COMP:13258
+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrofolate synthase/folylpolyglutamate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionA0AAX0HUP7
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length432
- Mass (Da)45,388
- Last updated2024-11-27 v1
- MD5 ChecksumF32DC16DC421830827F9700F0D8F3BE0
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MKCQ01000023 EMBL· GenBank· DDBJ | OEY88167.1 EMBL· GenBank· DDBJ | Genomic DNA |