A0AAQ5BHD9 · A0AAQ5BHD9_HUMAN

  • Protein
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • Gene
    SDHB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster (UniProtKB | Rhea| CHEBI:21137 )

Note: Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • EC number

Gene names

    • Name
      SDHB

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0AAQ5BHD9

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein

Keywords

Disease & Variants

Variants

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The viewer provides 587 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

Interaction

Subunit

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-1312Fe-2S ferredoxin-type
Domain158-1884Fe-4S ferredoxin-type

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    262
  • Mass (Da)
    29,535
  • Last updated
    2024-10-02 v1
  • Checksum
    FB055932B9DDFC40
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV

Computationally mapped potential isoform sequences

There are 12 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P21912SDHB_HUMANSDHB280
A0AAQ5BHC2A0AAQ5BHC2_HUMANSDHB223
A0AAQ5BHC5A0AAQ5BHC5_HUMANSDHB43
A0AAQ5BHC9A0AAQ5BHC9_HUMANSDHB295
A0AAQ5BHA5A0AAQ5BHA5_HUMANSDHB126
A0AAQ5BHB4A0AAQ5BHB4_HUMANSDHB148
A0AAQ5BHE6A0AAQ5BHE6_HUMANSDHB179
A0AAQ5BH73A0AAQ5BH73_HUMANSDHB131
A0AAQ5BH80A0AAQ5BH80_HUMANSDHB88
A0AAQ5BH88A0AAQ5BH88_HUMANSDHB177
A0A087WWT1A0A087WWT1_HUMANSDHB266
A0A087WXX8A0A087WXX8_HUMANSDHB223

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL049569
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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