A0AAQ5BHD9 · A0AAQ5BHD9_HUMAN
- ProteinSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
- GeneSDHB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids262 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Catalytic activity
- (R)-malate + a quinone = enol-oxaloacetate + a quinolThis reaction proceeds in the forward direction.
- (S)-malate + a quinone = enol-oxaloacetate + a quinolThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Note: Binds 1 [3Fe-4S] cluster.
Note: Binds 1 [4Fe-4S] cluster.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0AAQ5BHD9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Variants
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The viewer provides 587 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
Interaction
Subunit
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 40-131 | 2Fe-2S ferredoxin-type | |||
Domain | 158-188 | 4Fe-4S ferredoxin-type | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length262
- Mass (Da)29,535
- Last updated2024-10-02 v1
- ChecksumFB055932B9DDFC40
Computationally mapped potential isoform sequences
There are 12 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P21912 | SDHB_HUMAN | SDHB | 280 | ||
A0AAQ5BHC2 | A0AAQ5BHC2_HUMAN | SDHB | 223 | ||
A0AAQ5BHC5 | A0AAQ5BHC5_HUMAN | SDHB | 43 | ||
A0AAQ5BHC9 | A0AAQ5BHC9_HUMAN | SDHB | 295 | ||
A0AAQ5BHA5 | A0AAQ5BHA5_HUMAN | SDHB | 126 | ||
A0AAQ5BHB4 | A0AAQ5BHB4_HUMAN | SDHB | 148 | ||
A0AAQ5BHE6 | A0AAQ5BHE6_HUMAN | SDHB | 179 | ||
A0AAQ5BH73 | A0AAQ5BH73_HUMAN | SDHB | 131 | ||
A0AAQ5BH80 | A0AAQ5BH80_HUMAN | SDHB | 88 | ||
A0AAQ5BH88 | A0AAQ5BH88_HUMAN | SDHB | 177 | ||
A0A087WWT1 | A0A087WWT1_HUMAN | SDHB | 266 | ||
A0A087WXX8 | A0A087WXX8_HUMAN | SDHB | 223 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL049569 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |