A0AAQ0F9K4 · A0AAQ0F9K4_BURCE

Function

function

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

GO annotations

AspectTerm
Molecular Functionnucleotidyltransferase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional uridylyltransferase/uridylyl-removing enzyme
  • Short names
    UTase/UR
  • Alternative names
    • Bifunctional [protein-PII] modification enzyme
    • Bifunctional nitrogen sensor protein

Including 2 domains:

  • Recommended name
    [Protein-PII] uridylyltransferase
  • EC number
  • Short names
    PII uridylyltransferase
    ; UTase
  • Recommended name
    [Protein-PII]-UMP uridylyl-removing enzyme
  • EC number
  • Short names
    UR

Gene names

    • Name
      glnD
    • ORF names
      DPR02_25100

Organism names

  • Taxonomic identifier
  • Strain
    • PT02
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0AAQ0F9K4

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-323Uridylyltransferase
Domain443-565HD
Domain682-761ACT
Domain790-858ACT

Domain

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.

Sequence similarities

Belongs to the GlnD family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    858
  • Mass (Da)
    97,127
  • Last updated
    2024-10-02 v1
  • MD5 Checksum
    97A46D58BC2C4FD2056E12575DD29146
MSAHAAPSPDALSRRAEFKAAKTEMLERFRRATNVASLMHALSKLTDDALKRVWDDCGLPATLALVAVGGYGRGELAPYSDVDILVLLPDAHDPTLDARIERFIGMAWDLGLEIGSSVRTVAQCIEEASQDVTVQTSLLEARRIVGSTALFERFTVRYHEALDARAFFTAKVLEMRQRHAKFQDTPYSLEPNVKESPGGLRDLQTILWIARAAGFGSSWRELDTRGLITDREARELRRNEGFLKTLRARLHVIAGRRQDMLVFDLQTQAAESFGYQPTQTKRASEQLMRRYYWAAKAVTQLATILIQNIEAQLFPATSGITRVLSPDRFVEKQGMLEIVDDGVFERHPDAILEAFLLYETTRGVKGLSARTLRALYNSREIMNNAWRRDPQNRDTFMRILQQPEGITHAFRLMNQTSVLGRYLLNFRRIVGQMQHDLYHVYTVDQHILMVLRNIRRFAVAEHAHEYPFCSQLIGNFERPWVLYVAALFHDIAKGRGGDHSTLGMADARRFCREHGIAGDDASLIVWLVQHHLTMSQVAQKQDTSDPEVIKRFAEVVGNERYLTALYLLTVADIRGTSPKVWNTWKGKLLEDLYRITLAVLGGANPDAHSELKSRQEQALALLRLETVPDDAHRALWDQLDVGFFLRHDAADIAWQTRVLYRHVNAEIAIVRARPSPIGDALQVLVYVKDRPDLFAGICAYFDRNGLSVLDARVSTTRHGYALDNFIVTQTERDVRYRDIANLVEQQLASRLTETAPLPEPSKGRLSRLSRTFPITPRVDLRADERGQYYILSVSANDRPGLLYSIARVLAEHRIGVHAARINTLGERVEDIFLLAGAGLSDNRLQIQLETELLRAIAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QLUZ01000016
EMBL· GenBank· DDBJ
RAQ05339.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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