A0AAP9E7H5 · A0AAP9E7H5_RHIRD

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1905100200300400500600700800900
TypeIDPosition(s)Description
Binding site89ATP (UniProtKB | ChEBI)
Binding site107-111ATP (UniProtKB | ChEBI)
Binding site502ATP (UniProtKB | ChEBI)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      CG010_018060
      , J2W61_002992

Organism names

Accessions

  • Primary accession
    A0AAP9E7H5

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-615SecA family profile
Domain91-249Helicase ATP-binding
Domain423-623Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    905
  • Mass (Da)
    101,892
  • Last updated
    2024-10-02 v1
  • Checksum
    A1AA9CD9C8AA7C54
MVSLGGIARKLFGSANDRRVRSYKSKIAAINALEEATKALSDEALAAKTAEFRQQLADGKSLDDLLIPAFAVAREASRRVLHMRPFDVQLTGGMILHGGAIAEMKTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLAQRDAATMSRLYRFLGLTTGVIVHGLDDDQRREAYACDITYATNNELGFDYLRDNMKYDRAQMVQRGHNYAIVDEVDSILVDEARTPLIISGPLDDRSDLYNTIDAFIPLLAPEDYEIDEKQRSANFSEEGTEKLENLLRQAGLLKGESLYDVENVAIVHHINNALKAHKLFTRDKDYIVRNDEIVIIDEFTGRMMPGRRYSEGQHQALEAKEKVQIQPENQTLSSVTFQNYFRMYEKLAGMTGTASTEAEEFGNIYGLDVIEVPTNLPIQRIDEDDEVYRTGEEKFQAIITEIKAAHERGQPVLVGTTSIEKSELLAHMLRQSGFSDFQVLNARYHEQEAYIVSQAGVPGAVTIATNMAGRGTDIQLGGNVEMRLERELEGMEPGPELDAKEEAIRAEIKVLKEKALAAGGLYVIATERHESRRIDNQLRGRSGRQGDPGRSKFYLSLQDDLMRIFGSERMDSMLQKLGLKEGEAIVHPWINKALERAQKKVEARNFETRKNLLKYDDVLNDQRKVIFDQRLELMEADNIGETAADMRHEVIEMLVTKHVPENAYAEQWDIAGLKAGIAQFLNLDLPVEDWAKEEGIAEDDILQRVTEAADKYAAERAERFGPEIMTYVERSVILQTIDHLWREHIVNLDHLRSVVGFRGYAQRDPLQEYKAEAFELFQALLANLREAVTAQLMRVELVQQEPQQPELPEMTAHHLDPNTGEDEMAQGMQPTPVNFVPAEERDPNNPTTWGRIGRNEMCPCGSGKKYKHCHGVYEQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAVDSW010000002
EMBL· GenBank· DDBJ
MDR6703127.1
EMBL· GenBank· DDBJ
Genomic DNA
CP042275
EMBL· GenBank· DDBJ
QDY96091.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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