A0AAP4RQL8 · A0AAP4RQL8_BURCE

Function

function

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site327-333ATP (UniProtKB | ChEBI)
Binding site348ATP (UniProtKB | ChEBI)
Active site383

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase kinase/phosphatase
  • EC number
  • Short names
    IDH kinase/phosphatase
    ; IDHK/P

Gene names

    • Name
      aceK
    • ORF names
      E3D37_38545

Organism names

Accessions

  • Primary accession
    A0AAP4RQL8

Proteomes

Subcellular Location

Cytoplasm

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-321Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Domain322-576Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase

Sequence similarities

Belongs to the AceK family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    70,035
  • Last updated
    2024-10-02 v1
  • MD5 Checksum
    CFEF4F0CC4293DC1AFB435F08F434808
MNHFPKLLSSQIGFDVAQTMLENFDRHYRIFRDAAVEAKTLFEHGDWHGLQRLARERITSYDDRVKECVEVLEDEYDAENIDDEVWQQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYLENDEPAAKPTYRAYYPGTDGLAATLERIVTNFQLEPAFDDLPRDIGCVMQAIHDEFGHFDEAPNFQIHVLSSLFFRNKSAYIVGRIINADRVLPFAVPIRHVRPGVLSLDTVLLRRDQLMIIFGFSHSYFLVDMGVPSAYVDFLCTIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKIIKDHFPPPKETTRAQIMEKYQLVKRHDRLGRMADTLEYSSVALPLARLDHALVRELEKEVPSLLEYEDDNLVIKHLYIERRMTPLNLYLQNGSDTDIEHGVKEYGNAVKELMKANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNEEDELSGEPWYTVGPHDIFPETYGPFLLGDPRVRDVFMKHHADFFDPALWQASKDKLLQGELPDFYPYDASLRFSVRYPERFGATDQNDGEGDAQRAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SNSQ01000072
EMBL· GenBank· DDBJ
TEU34705.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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