A0AAP4RQL8 · A0AAP4RQL8_BURCE
- ProteinIsocitrate dehydrogenase kinase/phosphatase
- GeneaceK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids605 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Catalytic activity
- L-seryl-[isocitrate dehydrogenase] + ATP = O-phospho-L-seryl-[isocitrate dehydrogenase] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 327-333 | ATP (UniProtKB | ChEBI) | |||
Binding site | 348 | ATP (UniProtKB | ChEBI) | |||
Active site | 383 | ||||
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsocitrate dehydrogenase kinase/phosphatase
- EC number
- Short namesIDH kinase/phosphatase ; IDHK/P
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0AAP4RQL8
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 17-321 | Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory | |||
Domain | 322-576 | Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase | |||
Sequence similarities
Belongs to the AceK family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length605
- Mass (Da)70,035
- Last updated2024-10-02 v1
- MD5 ChecksumCFEF4F0CC4293DC1AFB435F08F434808
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
SNSQ01000072 EMBL· GenBank· DDBJ | TEU34705.1 EMBL· GenBank· DDBJ | Genomic DNA |