A0AAN8LDI2 · A0AAN8LDI2_9TELE
- ProteinHedgehog protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Protein hedgehog N-product
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
Protein hedgehog
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Catalytic activity
- glycyl-L-cysteinyl-[protein] + cholesterol + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHedgehog protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Coregoninae > Coregonus
Accessions
- Primary accessionA0AAN8LDI2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Sonic hedgehog protein
Protein hedgehog N-product
Cell membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-27 | ||||
Chain | PRO_5042962984 | 28-476 | Hedgehog protein | ||
Keywords
- PTM
Interaction
Subunit
Multimer.
Structure
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)53,234
- Last updated2024-10-02 v1
- ChecksumDC14552D1659DC30
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAGTTL010000019 EMBL· GenBank· DDBJ | KAK6308430.1 EMBL· GenBank· DDBJ | Genomic DNA |