A0AAN8KY36 · A0AAN8KY36_9TELE

  • Protein
    5'-3' exonuclease PLD3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.
    EC:3.1.16.1 (UniProtKB | ENZYME | Rhea)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'-3' exonuclease PLD3
  • EC number
  • Alternative names
    • Choline phosphatase 3
    • Phosphatidylcholine-hydrolyzing phospholipase D3
    • Phospholipase D3

Gene names

    • ORF names
      J4Q44_G00330980

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Cs_M1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Coregoninae > Coregonus

Accessions

  • Primary accession
    A0AAN8KY36

Proteomes

Subcellular Location

Early endosome membrane
; Single-pass type II membrane protein
Endoplasmic reticulum membrane
; Single-pass type II membrane protein
Late endosome membrane
; Single-pass type II membrane protein
Lysosome lumen

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-51Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain191-218PLD phosphodiesterase
Domain406-432PLD phosphodiesterase

Sequence similarities

Belongs to the phospholipase D family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    54,084
  • Last updated
    2024-10-02 v1
  • Checksum
    FD8683E8BE6A9D35
MISDIPYEKMCDVESRREESRRKAQMYYRCLLGLTGVATLLLAALFLQTLLLPVVNSSPNKPGFKLPLPLTDTCTDPCKIVLLESIPEGLEFNSSVTNPSIYQAWLNLISEARSSVDIASFYWTLTNKDTGSHEPTANQGEDVLNRLAQVSGKLSVRIAVNTPTKSQPQEDINLLKSSGADVRAVNMRDLTTGVLHTKFWVVDNKHIYIGSANMDWRSLTQVKELGAVVYNCSCLAADLGKIFEAYWYLGQKDTPIPSPWPSSFNTPYNKDTPLQLPLNGTASSVYLSSSPPSFCAAGRTGDLQSILSVMEDAREFVYIAVMNYLPTMEFSQPKRYWAEIDTQIRRVAYEKRVKVRLLISCWASSSPVMIPFLKALDSMQEPKAKLDVQVKLFVVPANPKQKEIPFARVNHNKYMVTDKVAYIGTSNWSGDYFVNTAGSALVVNQTAAQSAEPTVQAQLQAVFERDWDSAYSTPILQHTDLKMVC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGTTL010000032
EMBL· GenBank· DDBJ
KAK6296956.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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