A0AAN8KY36 · A0AAN8KY36_9TELE
- Protein5'-3' exonuclease PLD3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids485 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
Catalytic activity
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5'-3' exonuclease PLD3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Coregoninae > Coregonus
Accessions
- Primary accessionA0AAN8KY36
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Single-pass type II membrane protein
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Late endosome membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 26-51 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)54,084
- Last updated2024-10-02 v1
- ChecksumFD8683E8BE6A9D35
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAGTTL010000032 EMBL· GenBank· DDBJ | KAK6296956.1 EMBL· GenBank· DDBJ | Genomic DNA |