A0AAN8H606 · A0AAN8H606_CHAGU

Function

function

Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  • (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
    This reaction proceeds in the forward direction.
    EC:2.6.1.40 (UniProtKB | ENZYME | Rhea)
  • 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
    EC:2.6.1.44 (UniProtKB | ENZYME | Rhea)
  • N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
  • 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
  • 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
  • 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
    This reaction proceeds in the backward direction.
    EC:2.6.1.18 (UniProtKB | ENZYME | Rhea)
  • oxaloacetate + L-alanine = L-aspartate + pyruvate
  • L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  • N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
  • N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  • N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  • N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
  • glyoxylate + L-alanine = glycine + pyruvate
    This reaction proceeds in the forward direction.
    EC:2.6.1.44 (UniProtKB | ENZYME | Rhea)
  • L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  • N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
  • N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  • N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alanine--glyoxylate aminotransferase 2, mitochondrial
  • EC number
  • Alternative names
    • (R)-3-amino-2-methylpropionate--pyruvate transaminase
    • Beta-ALAAT II
    • Beta-alanine-pyruvate aminotransferase
    • D-3-aminoisobutyrate-pyruvate aminotransferase
    • D-AIBAT
    • D-beta-aminoisobutyrate-pyruvate aminotransferase

Gene names

    • ORF names
      CgunFtcFv8_025735

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Channichthyidae > Champsocephalus

Accessions

  • Primary accession
    A0AAN8H606

Proteomes

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    56,788
  • Last updated
    2024-10-02 v1
  • Checksum
    5FFCFB1960EF0E1F
MFKVVHRLAGRCAVVSGQSCCSPASAKLHLGVGAVCQKPAHRHRPADLPEMPSCDFKPGEYKGMSKERIMEIRRKNCNPMTMKITYYKKPVFLHQGYMQWLWDFDGNRYLDLFAGVATVSVGHCHPKVAAALQRQLNKLWHTTNIYVNPTLHEYSEKLASHLPDPLKVVYLTNSGSEANDLAMLMARLHTGNFDLLTLRGSYHGGTQQTMGLTSNSSYKYPIATSSGCTHTMCPDVFRGPWGGSHCRDSPVQTTRQCSCAQGHCMANDQYIGQLKETFATSVPSRIAGFFGEPIQGMGGAVQYPKNYLKEAYQLVRERGGVCIADEVQTGFGRTGSHFWGFQGHDVLPDMVTMAKGIGDGFPMGAVVTTPEIAASFAKAFHFNTFGGGPLACAVASSVLDTIKEDGTQQNSHNVGTYLMTELAKLRDTYEIIGDVRGKGLQIGVEMVTNKASRDPLSPEAMSEIFEDIKEMGVLIGKGGVYGQAFRIQPPMCITKEDVKFFLAVFKKAIQRYMDKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAURVH010001532
EMBL· GenBank· DDBJ
KAK5900804.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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