A0AAN8DE45 · A0AAN8DE45_CHAGU
- ProteinKidney mitochondrial carrier protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids285 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate.
Catalytic activity
- (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)(2R,3R)-tartrate (in)CHEBI:30924
+ sulfate (out)CHEBI:16189= (2R,3R)-tartrate (out)CHEBI:30924+ sulfate (in)CHEBI:16189 - (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)
- (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)
- (S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)
- (S)-malate(out) = (S)-malate(in)
- (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)
- D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
- L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
- maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
- malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
- oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
- sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out)
- phosphate(in) = phosphate(out)
- sulfate(out) + succinate(in) = sulfate(in) + succinate(out)
- sulfate(in) = sulfate(out)
- sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
- thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameKidney mitochondrial carrier protein 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Channichthyidae > Champsocephalus
Accessions
- Primary accessionA0AAN8DE45
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length285
- Mass (Da)31,470
- Last updated2024-10-02 v1
- Checksum60E5477BC7A97A8E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAURVH010001524 EMBL· GenBank· DDBJ | KAK5919218.1 EMBL· GenBank· DDBJ | Genomic DNA |