A0AAN7UPQ0 · A0AAN7UPQ0_9PEZI
- ProteinFanconi-associated nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids859 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariaceae > Xylaria
Accessions
- Primary accessionA0AAN7UPQ0
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-93 | Disordered | |||
Compositional bias | 8-22 | Polar residues | |||
Compositional bias | 23-46 | Basic and acidic residues | |||
Compositional bias | 64-87 | Basic and acidic residues | |||
Compositional bias | 310-336 | Polar residues | |||
Region | 310-345 | Disordered | |||
Domain | 737-853 | VRR-NUC | |||
Sequence similarities
Belongs to the FAN1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length859
- Mass (Da)98,828
- Last updated2024-10-02 v1
- ChecksumD032C0629680EE6B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 8-22 | Polar residues | |||
Compositional bias | 23-46 | Basic and acidic residues | |||
Compositional bias | 64-87 | Basic and acidic residues | |||
Compositional bias | 310-336 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAWHQM010000028 EMBL· GenBank· DDBJ | KAK5632907.1 EMBL· GenBank· DDBJ | Genomic DNA |