A0AAN7UPQ0 · A0AAN7UPQ0_9PEZI

  • Protein
    Fanconi-associated nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      RRF57_008621

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GMP-LS
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariaceae > Xylaria

Accessions

  • Primary accession
    A0AAN7UPQ0

Proteomes

Subcellular Location

Nucleus

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-93Disordered
Compositional bias8-22Polar residues
Compositional bias23-46Basic and acidic residues
Compositional bias64-87Basic and acidic residues
Compositional bias310-336Polar residues
Region310-345Disordered
Domain737-853VRR-NUC

Sequence similarities

Belongs to the FAN1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    859
  • Mass (Da)
    98,828
  • Last updated
    2024-10-02 v1
  • Checksum
    D032C0629680EE6B
MMDAFLNNVKPNTRSTPQLKDKSTLLAEEHPKKKVKREETDDSDTDSVNYQIHGPPLKTWPLLPKERDGLDNSADDDVIERSETEDTNISRSTAIDSSLPEIKLDKKAIEDYQNFKSSQENDVSNASTRLDSRAWERGNSSLYVDAFNLALDTVLDEEAHLFDRKEKRVFDEWKSLDYEAQFLYVRLFLRKTSSWHRIARLRYYNDITDTEAAVKVLQKNRDLTSETSPVQQSPIPELSSFIQERCGFEDAFTFADASEDFIDSVEESISLLTLDELKVLAKEAKVQGKNKSDLTKAVCRMSNQQAGLLSMGLRRTDTAESAESSGQETPTPDRRSPMSGSGDDGNRRKHFLDKILAVAGPCVRLSLPVFKLFERVHLVFYRSTEWTEKSLTTIILAKISRRNFPSYIVSRSSNIFTSRSQLLEFETAMKSNYTVDSILEFNGPITEKGFQKVIDVFETIYPRWICILQEEQEKEEWIYESGEGTYLRRLSPGHAYTRIIHKAAYVFGRLKEHRREHEVLSELLSQHLFHLARRGSWYQRKALLEEHYMHALLPNPAYTDPERQKNHWKSIAAATCEKALEDPDCHLKYHYDLQKRLVKLEKQLKIPVRLQHDFGHVQLKRPEQHHVEGIQLKKLDSIGKNGRGPSTKTIWIDEAEGGGECTVEAMCLSWYRSQGWKGYHAEGGIIRTLFAYLFFDILFLYIPNVFQTAYQTCPLDLHTDAFYRTRASEINHRLVEIANARAPQLIKEVDKREREKRTCIVGLNWDYELEDLLELADCFDGEALATVCKVMAQDYGQRGGGIPDLILWRAEPQKECMFAEVKSANDRLSDTQRLWIHVLTGAGLRVALCNAVAKEVREI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias8-22Polar residues
Compositional bias23-46Basic and acidic residues
Compositional bias64-87Basic and acidic residues
Compositional bias310-336Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAWHQM010000028
EMBL· GenBank· DDBJ
KAK5632907.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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