A0AAN7UIF1 · A0AAN7UIF1_9PEZI
- ProteinDNA replication ATP-dependent helicase/nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1553 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication ATP-dependent helicase/nuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariaceae > Xylaria
Accessions
- Primary accessionA0AAN7UIF1
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-100 | Disordered | |||
Compositional bias | 65-79 | Basic and acidic residues | |||
Compositional bias | 84-99 | Polar residues | |||
Region | 115-145 | Disordered | |||
Compositional bias | 124-138 | Basic and acidic residues | |||
Region | 229-338 | Disordered | |||
Compositional bias | 263-293 | Polar residues | |||
Domain | 467-666 | DNA replication factor Dna2 N-terminal | |||
Domain | 674-777 | DUF83 | |||
Domain | 838-929 | DNA2 rift barrel | |||
Domain | 1031-1118 | DNA2/NAM7 helicase helicase | |||
Domain | 1132-1199 | DNA2/NAM7 helicase helicase | |||
Domain | 1207-1435 | DNA2/NAM7 helicase-like C-terminal | |||
Region | 1483-1530 | Disordered | |||
Sequence similarities
Belongs to the DNA2/NAM7 helicase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,553
- Mass (Da)173,255
- Last updated2024-10-02 v1
- Checksum45939F88E29180CB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 65-79 | Basic and acidic residues | |||
Compositional bias | 84-99 | Polar residues | |||
Compositional bias | 124-138 | Basic and acidic residues | |||
Compositional bias | 263-293 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAWHQM010000003 EMBL· GenBank· DDBJ | KAK5625901.1 EMBL· GenBank· DDBJ | Genomic DNA |