A0AAN7UIF1 · A0AAN7UIF1_9PEZI

  • Protein
    DNA replication ATP-dependent helicase/nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication ATP-dependent helicase/nuclease
  • EC number

Gene names

    • ORF names
      RRF57_001617

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GMP-LS
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariaceae > Xylaria

Accessions

  • Primary accession
    A0AAN7UIF1

Proteomes

Subcellular Location

Mitochondrion
Nucleus
Chromosome

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-100Disordered
Compositional bias65-79Basic and acidic residues
Compositional bias84-99Polar residues
Region115-145Disordered
Compositional bias124-138Basic and acidic residues
Region229-338Disordered
Compositional bias263-293Polar residues
Domain467-666DNA replication factor Dna2 N-terminal
Domain674-777DUF83
Domain838-929DNA2 rift barrel
Domain1031-1118DNA2/NAM7 helicase helicase
Domain1132-1199DNA2/NAM7 helicase helicase
Domain1207-1435DNA2/NAM7 helicase-like C-terminal
Region1483-1530Disordered

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,553
  • Mass (Da)
    173,255
  • Last updated
    2024-10-02 v1
  • Checksum
    45939F88E29180CB
MGVSFSEQNGSLRTRQRWHKSRSHSAITQPSTALDARSRPLERVTDATKHKLNAFNFRPPAQAPEPHEPVKREFLDENDSPAQCDAASLPSNLPSAPMKHLSTPVNRLAWQDLIGDSDVNPEDEDFSPQEKIEWDTKQKPSPRTVAPAVNVRKLSAALKSPHADPAIELWDRFSLSGSTTTTPLGAANPAFAEIMVSSSPKPPQYVEAGRGDGVLRRAISCGANWPKRRRVERTETAPSIDLNALKSPSPRKRRYNPATHLSGSPKRRLSSSKSPPLQTSEAAGVSKEPSNVDASSDYGDDDFDDDTLMNLDVTISSALEQEPRPQPRTPELKETMNPNHAAPSVDISFDEFADLDDDLFADAGDLLSQIDSACTFGQGTGASQAPAFKSAVPQQPALDDSAEDMYGDDFGDFDFEAAEIAATQQSAKKPTGSVPLRASGEGKYPKITASPVANIFKILFVELDRAKIMKTVYLRGDWVETPASPKSYIHIIGDFEPSGRCVIDNLQNILILHPDQLISATVVADSFTCMRRSVLQDRVKATSEKTPPLVYGTLLHEIFQEALLANDWSSGFLDTVICKITEKHVEDLYIIKVAVADSRNHLRSKMPELQAWAKTFVSAFPKPDAIVQGRSGDKANMSVTKLLDVEEHVWSPMYGLKGNIDATVQVTMKEGSQRRTLTVPFEVKTGKNATPNHMAQTALYNLLLSDRYDIKIAYGVLYYMETSQMYRIPTIRNELRHMILQRNQLACYVRERSVQLPPMKKSANTCGKCYAKVSCFIYHKLADDGNAETSGVKGKFEEVVQHLTPTHQEFFLKWERLLTKEEKEGQKLRRELWTMVSTEREKVGRCFANVIIEEGTAFEDSDGPKINRYRYTFVKEDASSAFSFLDSQLTVGEPIVVSDETGHFALALGYVTSVRKQRISVAVDRRLHNARIRRPGFDENTNQVFASIMEVVPEGAMPSQSQGKLKEAPLRYRLDKDEFSNGMATVRNNLIQVMADGVFGSKEIRRLVVDLVPPRFKATTTQYSMSEQASLNVDQKRAIQKVMSAEDYALVLGMPGTGKTTTIAHIIRALVSQGKSVLLTSYTHSAVDNILLKLKTDQFPILRLGAPAKVHPEVQDFAILANQPMSNFEEIRHAWHDSPVVATTCLGVNHPIFNERTFDYCIVDEASQITLPICLGPIRLARTFVLVGDHNQLPPLVQNEEAREGGLDISLFKLLSDTHPDSVVNLEHQYRMCEDVMTLSNTLIYEGRLKCGTEALRHQKLVIPQMNHLRQKHYDKNTIMRPGTPRSFCVNWRSNHCWLHHLLDPEARVRFVNTDQLPAPREEAKGNRIVNPTEARIVVQLIDSLIAVGVPANEIGVMTHYRSQLSLLKHGLRGFGNSIELHTADRFQGRDKEVVVLSLVRSNEACSIGDLLKDWRRINVAFTRAKTKLLVVGSRETLKGSGEQEMLSRFIRLMEDRDWVYDLPRDALESHFFEEGATQFTATGAPGSLASPSKKSPKKSPRKGATSMKSNQFFAGKENRRPAAKRGNVTGRALLRNNPVSRDILNEMMEGVY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias65-79Basic and acidic residues
Compositional bias84-99Polar residues
Compositional bias124-138Basic and acidic residues
Compositional bias263-293Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAWHQM010000003
EMBL· GenBank· DDBJ
KAK5625901.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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