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A0AAN5I7L4 · A0AAN5I7L4_9BILA

  • Protein
    Katanin p60 ATPase-containing subunit A1
  • Gene
    KATNA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site242-249ATP (UniProtKB | ChEBI)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • ORF names
      PMAYCL1PPCAC_23506

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RS5460
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Diplogasteromorpha > Diplogasteroidea > Neodiplogasteridae > Pristionchus

Accessions

  • Primary accession
    A0AAN5I7L4

Proteomes

Subcellular Location

Cytoplasm, cytoskeleton
Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region73-175Disordered
Compositional bias113-175Basic and acidic residues
Domain234-371AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    53,569
  • Last updated
    2024-10-02 v1
  • MD5 Checksum
    663B7489B84EF62C41CD85A6039EE4CC
MEQLYRDISSARKAAKDGAYSHSLVLYTSILGQMNKMMTEGAIESGRTEWVQARAKLSNEMALVKKLEKDINDLKLGDDQPSTETPPSDPDVWPLPPPRKTTGGMRGRGMTKGGTSRSREEEKKREERRGEKSMLRKSNSQNGMDRRDKEQPALKKGESTDGRDGRNSEDDQRREQLAKYDKELVDTIERDILQKNLDVRWSSIAGLEDAKKLLKEAVILPTVLPHFFKGIRRPWKGVCMVGPPGTGKTLLAKAVATECKTTFFSVSSSTLTSKYRGDSEKLVRLLFEMARLYAPSTIFIDEIDSLGGRRGSEGEHEASRRVKSQLLVEMDGCSVDAEKPVLVLAATNFPWELDEALRRRLEKRIYIPLPDLAARESLLRISLEEVELAAGVDLAEMAKLLDGFSGADMTNVCREASMMGLRRLTESLDAMQIAALANQKVDLPVTRDDLLTAIKRTSPSVSQKDVEKYAVWMREFGAV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias113-175Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BTRK01000005
EMBL· GenBank· DDBJ
GMR53311.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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