A0AAN3G5Q7 · A0AAN3G5Q7_XANCI

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site100L-glutamine (UniProtKB | ChEBI)
Binding site307L-glutamine (UniProtKB | ChEBI)
Binding site309L-glutamine (UniProtKB | ChEBI)
Active site335Nucleophile
Binding site336L-glutamine (UniProtKB | ChEBI)
Binding site339L-glutamine (UniProtKB | ChEBI)
Binding site377L-glutamine (UniProtKB | ChEBI)
Binding site379L-glutamine (UniProtKB | ChEBI)
Binding site380L-glutamine (UniProtKB | ChEBI)
Active site419
Active site421

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      carA
    • ORF names
      XAUC_26900

Organism names

Accessions

  • Primary accession
    A0AAN3G5Q7

Proteomes

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-258CPSase
Region17-53Disordered
Domain56-186Carbamoyl-phosphate synthase small subunit N-terminal

Sequence similarities

Belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    444
  • Mass (Da)
    47,618
  • Last updated
    2024-10-02 v1
  • Checksum
    E4B3BA537739A3C2
MLFRLAWRGSCLYNSRLPEPASDRSPAPRPRFAATGIWPGAHRSPRQPERDPHVTQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHIGNTGFTDQDDEARKIWAAGLIVRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTRLLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKVVSTESTYTWKEGSLDLNSDSFLGLGALNIGKSAHGSAGSGEGLAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAEVLALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMTTGHHGANHPVQDLDGGRVMITSQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPAFSFQGHPEASPGPRDVGPLFDRFVDLMAARA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACPY01000225
EMBL· GenBank· DDBJ
EFF46943.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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