A0AAN1S1R0 · A0AAN1S1R0_ECO1A

Function

function

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site12Proton acceptor
Binding site78substrate
Binding site152substrate
Binding site173-174substrate
Active site197Proton donor

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
  • EC number
  • Short names
    MTA/SAH nucleosidase
    ; MTAN
  • Alternative names
    • 5'-deoxyadenosine nucleosidase
      (DOA nucleosidase
      ; dAdo nucleosidase
      )
    • 5'-methylthioadenosine nucleosidase
      (MTA nucleosidase
      )
    • S-adenosylhomocysteine nucleosidase
      (AdoHcy nucleosidase
      ; SAH nucleosidase
      ; SRH nucleosidase
      )

Gene names

    • Name
      pfs
    • Synonyms
      mtnN
    • Ordered locus names
      ECO111_0161

Organism names

Accessions

  • Primary accession
    A0AAN1S1R0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-226Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    232
  • Mass (Da)
    24,368
  • Last updated
    2024-10-02 v1
  • MD5 Checksum
    94FA0C308E5ED7671A4254242329C167
MKIGIIGAMEEEVTLLRDKIEKRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP010960
EMBL· GenBank· DDBJ
BAI34160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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