A0AAN1S1R0 · A0AAN1S1R0_ECO1A
- Protein5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Genepfs
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids232 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
Catalytic activity
- 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 12 | Proton acceptor | |||
Binding site | 78 | substrate | |||
Binding site | 152 | substrate | |||
Binding site | 173-174 | substrate | |||
Active site | 197 | Proton donor | |||
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- EC number
- Short namesMTA/SAH nucleosidase ; MTAN
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0AAN1S1R0
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length232
- Mass (Da)24,368
- Last updated2024-10-02 v1
- MD5 Checksum94FA0C308E5ED7671A4254242329C167
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP010960 EMBL· GenBank· DDBJ | BAI34160.1 EMBL· GenBank· DDBJ | Genomic DNA |