A0AAN0R6R8 · A0AAN0R6R8_9PSED

  • Protein
    Anthranilate synthase component 1
  • Gene
    trpE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

GO annotations

AspectTerm
Molecular Functionlyase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate synthase component 1
  • EC number

Gene names

    • Name
      trpE
    • ORF names
      PVLB_23120

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • VLB120
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0AAN0R6R8

Proteomes

Interaction

Subunit

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-167Anthranilate synthase component I N-terminal
Domain223-476Chorismate-utilising enzyme C-terminal

Sequence similarities

Belongs to the anthranilate synthase component I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    54,486
  • Last updated
    2024-10-02 v1
  • Checksum
    16B011E1993DF166
MTREEFLRLAAAGYNRIPLACETLADFDTPLSIYLKLADQPNSYLLESVQGGEKWGRYSMIGLPSRTVMRVHGYHVSILQDGVEVENHDVEDPLAFVETFKDRYKVADIPGLPRFNGGLVGYFGYDCVRYVEKRLGACPNPDPLGVPDILLMVSDAVVVFDNLAGKMHAIVLVDPTEEQAFEQGQARLQGLLETLRQPITPRRGLDLSGPLAAEPEFRSSYTRDDYENAVGRIKEYILAGDCMQVVPSQRMSIDFKAAPIDLYRALRCFNPTPYMYFFNFGDFHVVGSSPEVLVRVEDNLVTVRPIAGTRPRGATEEADRALEDDLLSDEKEIAEHLMLIDLGRNDVGRVSSTGSVRLTEKMVIERYSNVMHIVSNVTGQLRQGLTAMDALRAILPAGTLSGAPKIRAMEIIDELEPVKRGVYGGAVGYFAWNGNMDTAIAIRTAVIKDGELHVQAGGGIVADSVPALEWEETINKRRAMFRAVALAEQTSAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003961
EMBL· GenBank· DDBJ
AGZ37403.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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