A0AAJ7XJU4 · A0AAJ7XJU4_PETMA
- ProteinZona pellucida sperm-binding protein 3
- GeneLOC116958493
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids367 (go to sequence)
- Protein existenceInferred from homology
- Annotation score1/5
Function
function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Names & Taxonomy
Protein names
- Recommended nameZona pellucida sperm-binding protein 3
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Cyclostomata > Hyperoartia > Petromyzontiformes > Petromyzontidae > Petromyzon
Accessions
- Primary accessionA0AAJ7XJU4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Post-translational modification
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-291 | ZP | ||||
Sequence: MSPRADKSHESGRELRWLCWCRAKSRFFAVLAMETTRALFAVLELLCLASATVATSATVSVVCDEATLTLTVSRDLFGTGHLAQASDLSLGVPACPVTGSDALAGTVTFLYALESCGTSLQMSAGLLSYENYLYYRPTSNTGIIRTNYVAVPVVCLYPRRVHQQSLIYQLGQTLNVEASVQTLNHVPLRIFVVSCFATPVPDRNAPLCYQIISNSGCLVDGKVSYDAHLTSGFLLRQSDNVLRFFIDSFRFLATLTNNGDQVFVFCQLKVADVATSPTTVKKACTYSPSAA |
Domain
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence similarities
Belongs to the ZP domain family. ZPC subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length367
- Mass (Da)40,156
- Last updated2024-07-24 v1
- Checksum00FC1D17A2A85C6D