A0AAJ7BKR4 · A0AAJ7BKR4_CEPCN

Function

function

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell.

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Catalytic activity

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site103Ca2+ 1 (UniProtKB | ChEBI)
Binding site104Ca2+ 1 (UniProtKB | ChEBI)
Binding site104Ca2+ 2 (UniProtKB | ChEBI)
Binding site109Ca2+ 1 (UniProtKB | ChEBI)
Binding site139Ca2+ 1 (UniProtKB | ChEBI)
Binding site140Ca2+ 2 (UniProtKB | ChEBI)
Binding site140Ca2+ 1 (UniProtKB | ChEBI)
Binding site143Ca2+ 2 (UniProtKB | ChEBI)
Binding site154Zn2+ (UniProtKB | ChEBI)
Binding site161Zn2+ (UniProtKB | ChEBI)
Binding site196Zn2+ (UniProtKB | ChEBI)
Site211-212Cleavage; by autolysis
Site257Involved in cholesterol transfer
Site280Involved in auto-cleavage
Site283Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionmorphogen activity
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanatomical structure morphogenesis
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processintein-mediated protein splicing
Biological Processprotein autoprocessing
Biological Processregulation of gene expression
Biological Processsegment polarity determination
Biological Processsmoothened signaling pathway
Biological Processsystem development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • Name
      LOC107264577

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Cephoidea > Cephidae > Cephus

Accessions

  • Primary accession
    A0AAJ7BKR4

Proteomes

Subcellular Location

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-31
ChainPRO_504257815832-457Hedgehog protein

Keywords

Interaction

Subunit

Interacts with shf.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias200-220Polar residues
Region200-226Disordered
Domain210-308Hint
Domain332-376Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    51,145
  • Last updated
    2024-07-24 v1
  • Checksum
    E52661CA894B85B7
MVYIVVAPANHRKRAFLQILVLLSFWLPTLETGLVLGCGPGRGGGRRPMFRKLTPLVFKQHVPNVSENTLPASGLSEGRVSRHDSRFRDLVPNYNADIVFKDEEGTGADRLMTQRCKEKLNTLAISVMNQWPGVKLRVTEGWDEEGKHATDSLHYEGRAVDVTTSDRDRSKYGMLARLAVEAGFDWVYYESRSHIHCSVKSESSSAGKSGGCFPGSSQVRTEDGSRKRLDQLRLGERIAALDARGNLLYSEVIAFLDRSPKERRQFLELTTESGHVLTLTPAHLVPVQGKAAVFAARVQQGDRILVRDDDVRNNEMNQLNQLNQLNQINQINENLRWDRVARVELVLKEGIFAPLTTEGTLLVDDVVASCYAVVDSQMIAHYAFLPLRILNNLKSGIHRLASLMTGPVTSWKMPERRYSETIDVNATRHSAAATGVHWYASVLYSISAYVLPAQMLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias200-220Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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