A0AAJ6CLE4 · A0AAJ6CLE4_9BASI

  • Protein
    Adenylosuccinate synthetase
  • Gene
    ADE12
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site24-30GTP (UniProtKB | ChEBI)
Active site25Proton acceptor
Binding site25Mg2+ (UniProtKB | ChEBI)
Binding site25-28IMP (UniProtKB | ChEBI)
Binding site50-53IMP (UniProtKB | ChEBI)
Binding site52Mg2+ (UniProtKB | ChEBI)
Binding site52-54GTP (UniProtKB | ChEBI)
Active site53Proton donor
Binding site147IMP (UniProtKB | ChEBI)
Active site158
Binding site161IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site238IMP (UniProtKB | ChEBI)
Binding site253IMP (UniProtKB | ChEBI)
Binding site313-319substrate
Binding site317IMP (UniProtKB | ChEBI)
Binding site319GTP (UniProtKB | ChEBI)
Binding site345-347GTP (UniProtKB | ChEBI)
Binding site427-429GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      ADE12
    • ORF names
      MARU1_001358

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 13387
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Malasseziomycetes > Malasseziales > Malasseziaceae > Malassezia

Accessions

  • Primary accession
    A0AAJ6CLE4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    443
  • Mass (Da)
    48,624
  • Last updated
    2024-07-24 v1
  • Checksum
    F8D0FD6CC5B46997
MACMPKPDQSSRGRVTVVLGSQWGDEGKGKLTDMLSGEMDICARCAGGNNAGHTIVANVGPDNVKTKFDFHLLPSGLVNPKCIGFIGSGVVMHIPSFFSELDTTEKKGLKCDNRLFVSDRAHLVFDFHQVVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLYDFDTFAAKFRKLVEGRFKRYGNFEYDTEGEIARYRAFAERLRPFVVDGVTFIHSMLSSNRRVLVEGANALMLDLDYGTYPFVTSSSTGIGGVCTGLGIPPQSIGSVIGVMKAYTSRVGAGPFPTELSDEIMTHLQEVGAEYGTTTGRRRRCGWLDLVMMRYSTLINGYTSLNLTKLDVLDNLPEIKVATSYVLGEKELSSFPADLNILAKVDVKYKTFPGWEGPISNCKSYEELPQTCREYIEYIENFLGVRIEWIGVGPGREAMLHRPVSSA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP119917
EMBL· GenBank· DDBJ
WFD15340.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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