A0AAJ6A192 · A0AAJ6A192_9HYPH

  • Protein
    Ribose-phosphate pyrophosphokinase
  • Gene
    prs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34-36ATP (UniProtKB | ChEBI)
Binding site93-94ATP (UniProtKB | ChEBI)
Binding site127Mg2+ (UniProtKB | ChEBI)
Binding site167Mg2+ (UniProtKB | ChEBI)
Active site190
Binding site192D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site216D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site220-224D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      QA648_10075

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CB3171
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium

Accessions

  • Primary accession
    A0AAJ6A192

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-117Ribose-phosphate pyrophosphokinase N-terminal
Domain151-258Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    33,505
  • Last updated
    2024-07-24 v1
  • Checksum
    735821E22E486E4A
MKVFAGNSNRHLAEAICNYLNVPLGKASVRRFADQEIFVEIQENVRGEDVFVVQPTSFPTNDHLMELLIMIDAMRRSSARRITAVIPYFGYARQDRRASGRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLYAVPVLTRDIKVNYDISNVMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNIIGDVEGKDCLLIDDIVDSGGTLCNAADALLAQGAASVTAYITHGVLSGGAVTRITSSKLRELVITDSIQPTTAVLSAHNIRVVSAAGLIGEAINRTSQEESVSSLFD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP121652
EMBL· GenBank· DDBJ
WFU00525.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp