A0AAJ5Z6T6 · A0AAJ5Z6T6_9BASI

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site26-28substrate
Binding site54-58substrate
Binding site154substrate
Binding site201ATP (UniProtKB | ChEBI)
Binding site234-239ATP (UniProtKB | ChEBI)
Binding site265K+ (UniProtKB | ChEBI)
Binding site267K+ (UniProtKB | ChEBI)
Binding site270-271ATP (UniProtKB | ChEBI)
Active site271Proton acceptor
Binding site271substrate
Binding site306K+ (UniProtKB | ChEBI)
Binding site309K+ (UniProtKB | ChEBI)
Binding site311K+ (UniProtKB | ChEBI)
Binding site315K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiontransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      RBK1
    • ORF names
      MARU1_003013

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 13387
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Malasseziomycetes > Malasseziales > Malasseziaceae > Malassezia

Accessions

  • Primary accession
    A0AAJ5Z6T6

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-318Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    34,797
  • Last updated
    2024-07-24 v1
  • Checksum
    711D71C0A3F2F9E4
MVGVSVVEAASSAAIMSLCVVRSSVNIDETFQVPHIVRPGETISSSAMWSRPGGKGANVAAVLGLAGVRVRMLGAVGEDAKWPIRCLDERHVDTSCMYVSPDVPTGRAFIQLSQGDGENSIVLLKGANFALDTPLDDVQRWLSPEVTHLILQNEIPLASTIAYVQHAQSLSICTVFNPSPMLAPDELRAFPWAGLHVLIVNEGESAELQAALGPDAPTLADVPCLAPIPWLVVTRGSQGSRAGVILDGERTWIDVPASRTTHVVNTTGAGDTYTGYLVAGLMTTDHWTIDRVRAVLQRASVAAAMAVEVDGAMESIPAASEVEARCLSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP119921
EMBL· GenBank· DDBJ
WFD16969.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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