A0AAJ5Z143 · A0AAJ5Z143_9BASI
- ProteinAmmonium-dependent carbamoyl phosphate synthetase
- GeneCPA2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2159 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H+ + L-glutamate + phosphate
Pathway
Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ligase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmmonium-dependent carbamoyl phosphate synthetase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Malasseziomycetes > Malasseziales > Malasseziaceae > Malassezia
Accessions
- Primary accessionA0AAJ5Z143
Proteomes
Interaction
Subunit
Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Basic and acidic residues | ||||
Sequence: MGKKKGSKRDEDDPF | ||||||
Region | 1-243 | Disordered | ||||
Sequence: MGKKKGSKRDEDDPFADLGEDVSQNNEKAAQESEIPAEKEDKPAEEQQTGAPNDRQDPCEEAEAPVEVPRILTKKEKERLKKEREKEKKKAQAAQKKAAQQKQAPAEQEDTKETTMPEESKMPATEEQDEEEEADGAEGPTSAADKKKKKKKKKATEPAPAPRKAPNAAIAALQARLAAQKKAEEEERAREEERLRLIEEEERKEREEEERKEAERIRRKEKEKAKREQLRKEGKLLTPKQKA | ||||||
Compositional bias | 32-48 | Basic and acidic residues | ||||
Sequence: ESEIPAEKEDKPAEEQQ | ||||||
Compositional bias | 56-94 | Basic and acidic residues | ||||
Sequence: QDPCEEAEAPVEVPRILTKKEKERLKKEREKEKKKAQAA | ||||||
Compositional bias | 106-123 | Basic and acidic residues | ||||
Sequence: AEQEDTKETTMPEESKMP | ||||||
Compositional bias | 124-138 | Acidic residues | ||||
Sequence: ATEEQDEEEEADGAE | ||||||
Compositional bias | 179-243 | Basic and acidic residues | ||||
Sequence: AQKKAEEEERAREEERLRLIEEEERKEREEEERKEAERIRRKEKEKAKREQLRKEGKLLTPKQKA | ||||||
Region | 256-426 | Disordered | ||||
Sequence: LASGNISIAAKQGTDSEKPRRPMHDKKKKPQKKEPETAKEPAVEPAKEAAEEAVVDKVQPESNDDDAVKDEWDAESDNVKDDWEEESEEEPESAKEPVNEPTEQLSKEPAKEPVGKAPSNGASEAHESSDSDEDGSDDDEDMSTAQRMALDRRHTAEQRRKERTEKALAER | ||||||
Compositional bias | 284-320 | Basic and acidic residues | ||||
Sequence: KPQKKEPETAKEPAVEPAKEAAEEAVVDKVQPESNDD | ||||||
Compositional bias | 321-348 | Acidic residues | ||||
Sequence: DAVKDEWDAESDNVKDDWEEESEEEPES | ||||||
Compositional bias | 349-365 | Basic and acidic residues | ||||
Sequence: AKEPVNEPTEQLSKEPA | ||||||
Compositional bias | 396-426 | Basic and acidic residues | ||||
Sequence: DMSTAQRMALDRRHTAEQRRKERTEKALAER | ||||||
Domain | 431-650 | Tr-type G | ||||
Sequence: LRSPICCILGHVDTGKTKLLDKVRQTSVQEGEAGGITQQIGATYFPVEALREKTMVLNKGNFDFKVPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDIMHGLEAQTLESIRLLRDRKTPFIVALNKVDRLYDWKPTPNNAFQDSLAQQPVHTQKEFEERASKVMLAFAEQGLNAELYYKNKSMGRYVSLVPTSALSGEGVPDMLQLLVSLTQTRMSQS | ||||||
Domain | 1205-1397 | ATP-grasp | ||||
Sequence: VQALDEIQIPVARSEAVSTVKEALDAAKNIGYPVIVRAAYALGGLGSGFADSEEELRDLSARSLSLSPQILVEKSLRGWKESEYEVLRDQQDNALICCNMENFDPLGIHTGDSIVVAPSQTLSDDNYHMLRSAALKVIRHLGIVGECNIQYALSPDSREYRVIEVNPRLSRSSALASKATGYPLAYTAAKLGL | ||||||
Domain | 1742-1939 | ATP-grasp | ||||
Sequence: SQILDSIGVDQPAWVEVTDVEKAKKFARDVSYPVLVRPSYVLSGAAMNVIWDESTLEHNLTAAAQVNTDYPVVLTKFIPNAQEIDVDAVAHKGKLLVHAVSQHVENAGVHSGDATLVLPPFSLPQHDMERIKEISERVARAFDISGPYNMQIIRKVDPSTNESELKVIECNLRASRSFPFVSKVLGVNFIDVATNAIV | ||||||
Domain | 2007-2159 | MGS-like | ||||
Sequence: FRVPQPHKGVLLGGNIDTPEFKTIATKLYNLGFKLFCSNPDVEAFLNSIPHVAAKRIWFPLKDKRKLREVFDDYEIQFVINLAKYRAPSTTNEDYVARRNAVDFGLPLLNEPKTALLFVETLERKMPQGCLLPYEEGNIPSEVKAWNEFILPK |
Sequence similarities
Belongs to the CarB family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,159
- Mass (Da)240,293
- Last updated2024-07-24 v1
- Checksum32282B371A72573E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Basic and acidic residues | ||||
Sequence: MGKKKGSKRDEDDPF | ||||||
Compositional bias | 32-48 | Basic and acidic residues | ||||
Sequence: ESEIPAEKEDKPAEEQQ | ||||||
Compositional bias | 56-94 | Basic and acidic residues | ||||
Sequence: QDPCEEAEAPVEVPRILTKKEKERLKKEREKEKKKAQAA | ||||||
Compositional bias | 106-123 | Basic and acidic residues | ||||
Sequence: AEQEDTKETTMPEESKMP | ||||||
Compositional bias | 124-138 | Acidic residues | ||||
Sequence: ATEEQDEEEEADGAE | ||||||
Compositional bias | 179-243 | Basic and acidic residues | ||||
Sequence: AQKKAEEEERAREEERLRLIEEEERKEREEEERKEAERIRRKEKEKAKREQLRKEGKLLTPKQKA | ||||||
Compositional bias | 284-320 | Basic and acidic residues | ||||
Sequence: KPQKKEPETAKEPAVEPAKEAAEEAVVDKVQPESNDD | ||||||
Compositional bias | 321-348 | Acidic residues | ||||
Sequence: DAVKDEWDAESDNVKDDWEEESEEEPES | ||||||
Compositional bias | 349-365 | Basic and acidic residues | ||||
Sequence: AKEPVNEPTEQLSKEPA | ||||||
Compositional bias | 396-426 | Basic and acidic residues | ||||
Sequence: DMSTAQRMALDRRHTAEQRRKERTEKALAER |