A0AAJ5Z0Q6 · A0AAJ5Z0Q6_9BASI

  • Protein
    tRNA (guanine-N(7)-)-methyltransferase
  • Gene
    TRM8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.

Catalytic activity

Pathway

tRNA modification; N7-methylguanine-tRNA biosynthesis.

Features

Showing features for binding site, active site.

131720406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site88S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site111-112S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site189-190S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site209S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site212
Binding site287-289S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmethyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (guanine-N(7)-)-methyltransferase
  • EC number
  • Alternative names
    • Transfer RNA methyltransferase 8
    • tRNA (guanine(46)-N(7))-methyltransferase
    • tRNA(m7G46)-methyltransferase

Gene names

    • Name
      TRM8
    • ORF names
      MARU1_001851

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 13387
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Malasseziomycetes > Malasseziales > Malasseziaceae > Malassezia

Accessions

  • Primary accession
    A0AAJ5Z0Q6

Proteomes

Subcellular Location

Nucleus

Keywords

  • Cellular component

Interaction

Subunit

Forms a complex with TRM82.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-20Disordered
Region142-164Disordered

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    317
  • Mass (Da)
    36,236
  • Last updated
    2024-07-24 v1
  • Checksum
    4EEB46E0306F695C
MGKRKRSGRDASPSVLRQQEATHPNVISGRVVIPQKRWYRQRAHANPFSDHSLMYPAQPSDMDWSIHFPEMCARDAPVQKKVEFADVGCGFGGLLMRLAPLFPDTLMLGMEIRAQVTQYVHDKIHALRLAHKQAKTMSEKGKLELEAEVQPASDAQDEDSEERRQNEYLVKQAGHVAGGYQNIGVIRTNAMKFLPNFFEQGQLTKIFFLFPDPHFKARKHKARIISPTLLAEYAYVLRPGGIVYTVTDVRDLHEWMVKHLTDFPLFERIPDEALKEDPCVDAVMYSTEEGRKVERNEGDKFFAAFVRRDDPPVGEES

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP119918
EMBL· GenBank· DDBJ
WFD15827.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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