A0AAJ3YHW0 · A0AAJ3YHW0_9GAMM

  • Protein
    3-dehydroquinate dehydratase
  • Gene
    aroD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site47-493-dehydroquinate (UniProtKB | ChEBI)
Binding site833-dehydroquinate (UniProtKB | ChEBI)
Active site144Proton donor/acceptor
Active site171Schiff-base intermediate with substrate
Binding site2143-dehydroquinate (UniProtKB | ChEBI)
Binding site2333-dehydroquinate (UniProtKB | ChEBI)
Binding site2373-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • ORF names
      DFO57_102499

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AG702
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Pantoea

Accessions

  • Primary accession
    A0AAJ3YHW0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    251
  • Mass (Da)
    27,899
  • Last updated
    2024-07-24 v1
  • Checksum
    0071412D86C4FEF3
MTQTVRVKKIVFQAGQTRLCVPLTGRTREELQARAQLLTSAQADIIEWRVDHFIEGKDEKQVLLALADIRQQLGETPLLFTFRSKKEGGEMDISDDQYFALNHAAALSGLADVIDIELFNDESRIRSLVSEAHNAGVKVIMSNHDFHQTPAKEEIIYRLRRMQDLGADLPKIAVMPQTPQDVLTLLSATLLMKEHYATRPLITMSMGKMGGVSRVTGRLFGSAMTFGTLGQSSAPGQIAVTQLREMMETLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGTU01000002
EMBL· GenBank· DDBJ
PWW16753.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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