A0AAJ2T361 · A0AAJ2T361_9STRE
- Protein3-dehydroquinate dehydratase
- GenearoD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Catalytic activity
- 3-dehydroquinate = 3-dehydroshikimate + H2O
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 6 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 30-32 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: EWR | ||||||
Binding site | 62 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 118 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Active site | 143 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 186 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 205 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 209 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydroquinate dehydratase activity | |
Biological Process | 3,4-dihydroxybenzoate biosynthetic process | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate dehydratase
- EC number
- Short names3-dehydroquinase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA0AAJ2T361
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)25,611
- Last updated2024-07-24 v1
- ChecksumF9DFB006FBB1DEF4