A0AAJ2NNU9 · A0AAJ2NNU9_ALKPS
- ProteinLon protease
- Genelon
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids775 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalytic activity
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydrolase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLon protease
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Alkalihalophilus
Accessions
- Primary accessionA0AAJ2NNU9
Proteomes
Subcellular Location
Expression
Induction
By heat shock.
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-204 | Lon N-terminal | ||||
Sequence: IPLLPLRGLLVFPSMVLHLDVGRAKSVQALEFAMNEDEEILLSTQKEISIDEPTEDEIYSIGTIAKIKQLLKLPNGTVRIHVEGLYRAEIEQYVENAEFLEVDISPLTEEQKERTTETQAIMRSLLEMFEQYTKVSKKVSQETLATVSDITEPHRFADVLASNLPLKLAEKQELLEMNNVVERLLHLIDILNNEQ | ||||||
Domain | 592-773 | Lon proteolytic | ||||
Sequence: EDQVGAATGLAYTSAGGDTLSIEVSLAPGKGKLTLTGKLGDVMKESAQAAFSYIRARSKELEIEPDFHEKNDIHIHVPEGATPKDGPSAGITMATALISALTGRVVKKEVGMTGEITLRGRVLPIGGLKEKSMSAHRAGLKTIIIPKDNEKDLEDVPESVREDLNYILVGHLDDVLKHALGE |
Sequence similarities
Belongs to the peptidase S16 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length775
- Mass (Da)87,270
- Last updated2024-07-24 v1
- ChecksumF4B191703D15057A