A0AAJ2MCX2 · A0AAJ2MCX2_9ACTN

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site126(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site130-132(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site234Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      Q9R39_05770

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AC31
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    A0AAJ2MCX2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue235N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-394Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    46,529
  • Last updated
    2024-07-24 v1
  • Checksum
    0CCFD588AAE02910
MTANPSSLNSMSLAELDPDVAAAMNGELSRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGYPGRRYYGGCEYVDVVEDIARNRAKELFGADFANVQPHSGAQANAAVLQALMEPGETMLGLDLAHGGHLTHGMRLNFSGKLYENAFYGVSKEDFRIDMDEVRKIALDVKPKVIVAGWSAYPRTLDFEAFRSVADEVGAYLWVDMAHFAGLVAAGLHPSPVPHADVVSSTVHKTLGGPRSGIILAKQEWAKKLNSAVFPGQQGGPLMHAIAGKAVALKIAATDEFAERQRRTLSGARILAERLNGTDVAGAGVSVLTGGTDVHLVLVDLRNSALDGQQAEDLLHQVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFDDEQFTEVADIIATALAAGDAADVSALRGRVSKLALDFPLYDGLEEWGLMSRI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAUZVK010000003
EMBL· GenBank· DDBJ
MDT0220476.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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