A0AAJ2MCK9 · A0AAJ2MCK9_9ACTN

  • Protein
    Catalase-peroxidase
  • Gene
    katG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

Type
IDPosition(s)Description
Site107Transition state stabilizer
Active site111Proton acceptor
Binding site274Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • ORF names
      Q9R39_08035

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AC31
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    A0AAJ2MCK9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link233↔259Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-110)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-23Polar residues
Region1-37Disordered
Domain96-401Plant heme peroxidase family profile
Domain473-715Plant heme peroxidase family profile

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    741
  • Mass (Da)
    80,964
  • Last updated
    2024-07-24 v1
  • Checksum
    9CC86D8EC12AFBD4
MTSDSRPPNSDADTASASESENPAIPSPKPKAHAPLTNKDWWPEQIDLSILHAHSSLSNPLGEDFDYATEFEKLDVEALKADLVSLMTTSQDWWPADYGHYGGLFIRMSWHAAGTYRIFDGRGGGGQGAQRFAPLNSWPDNANLDKARRLLWPIKQKYGTKLSWADLLVFAGNVALESMGFKTFGFGFGREDIWEPEEVFWGPEDAWLGTDKRYSGERELAQPLGATTMGLIYVNPEGPEGKPDPIAAAEDIRETFGRMAMNDEETAALIIGGHSFGKTHGAGDADLIGPEPEGAPIEQQGLGWKSGYGKGKAEDTITSGLEVVWTSTPTQWGNGFLQNLYGYEWELTKSPAGAWQYVAKDGAGAGTIPDPFGGPGRAPTMLVTDVALRESPIYADITRRWLDHPEELAEAFAKAWYKLLHRDMGPVSRYLGPWVPEPQIWQDPVPAVDHELIDADDIASLKGTLLDALSPTQLIKTAWASAASFRSTDKRGGANGARIRLEPQKNWEINEPGELAKVLPVLEQVQKDFNDSASGGKKVSLADIIILGGAAAIEKAAEAAGFPVTVPFTPGRTDASQESTDVDSFEVLEPRADGFRNFSKDGEKTPLESLLLDRAYMLDLTAPELTVLVGGLRVLDTNYGGSKHGVFTDRPGVLSTDFFRNIIDMNTEWKSGSDENVYEGTDRATGEKKWTATAADLVFGSHSQLRALSEVYAQDDSAERFVNDFVKAWVKVSNNDRFDLA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-23Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAUZVK010000005
EMBL· GenBank· DDBJ
MDT0220915.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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