A0AAJ1XTY9 · A0AAJ1XTY9_9ENTE

  • Protein
    L-lactate dehydrogenase
  • Gene
    ldh
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of lactate to pyruvate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site21NAD+ (UniProtKB | ChEBI)
Binding site42NAD+ (UniProtKB | ChEBI)
Binding site47NAD+ (UniProtKB | ChEBI)
Binding site72NAD+ (UniProtKB | ChEBI)
Binding site86-87NAD+ (UniProtKB | ChEBI)
Binding site89substrate
Binding site95substrate
Binding site125-127NAD+ (UniProtKB | ChEBI)
Binding site127-130substrate
Binding site150NAD+ (UniProtKB | ChEBI)
Binding site155-158substrate
Binding site160beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site175beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site182Proton acceptor
Binding site236substrate

GO annotations

AspectTerm
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • ORF names
      RG666_07270

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FR191
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Enterococcus

Accessions

  • Primary accession
    A0AAJ1XTY9

Proteomes

Subcellular Location

Cytoplasm

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue227Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-149Lactate/malate dehydrogenase N-terminal
Domain152-320Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    35,487
  • Last updated
    2024-07-24 v1
  • Checksum
    E7D6F6D13D0C07AB
MTAAAGNKDHQKVILVGDGAVGSSYAFALVTQNIAQEVGIIDINVPKTEGDALDLSHALAFTSPKKIYAATYDDCHDADLVVLTAGAPQKPGETRLDLVHKNLKINKEIVTTIVDSGFNGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQAIAELVDVDARNVHAYILGEHGDTEFPVWSHANVAGLQIYEWVKNNPDVDEEAMVNLFFNVRDAAYTIIEKKGATFYGIAVALARITKAILNDENSVLPLSVYLEGEYGQNDIYIGAPAIINRQGVKQVIEIPLTDAEQEKMEASASALKEVIETAFAKFEAEEAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAKZIS010000003
EMBL· GenBank· DDBJ
MDQ8630708.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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