A0AAJ1TSS4 · A0AAJ1TSS4_9HYPH

Function

function

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-31NAD+ (UniProtKB | ChEBI)
Binding site56substrate
Binding site59substrate
Binding site94-97NAD+ (UniProtKB | ChEBI)
Active site112Proton acceptor
Binding site120Zn2+ (UniProtKB | ChEBI)
Binding site123Zn2+ (UniProtKB | ChEBI)
Binding site139Zn2+ (UniProtKB | ChEBI)
Binding site142Zn2+ (UniProtKB | ChEBI)
Binding site179-181NAD+ (UniProtKB | ChEBI)
Binding site205-207NAD+ (UniProtKB | ChEBI)
Binding site223NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydrolase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      QO001_005232

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 19569
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylobacterium

Accessions

  • Primary accession
    A0AAJ1TSS4

Proteomes

Subcellular Location

Cytoplasm

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-236Deacetylase sirtuin-type

Domain

2 residues (Tyr-56 and Arg-59) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    236
  • Mass (Da)
    25,254
  • Last updated
    2024-07-24 v1
  • Checksum
    35C5E7ECB681C86E
MGDPNNIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVIAAEPNAAHVALARAEARLAARGGRLFLCTQNVDDLHERAGSRAVVHMHGELLKARCTACGTVTPWRDDLDRASICPACGGVGRMRPDVVWFGEMPMHLDAIEDALAAADLFVAVGTSGAVYPAAGYVREARARNIPTCEINLEPSDNADAFDDARYGPASMALPRFLADLGL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAUSWL010000013
EMBL· GenBank· DDBJ
MDQ0546281.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp