A0AAJ1BLL0 · A0AAJ1BLL0_LIMRT

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

1884100200300400500600700800
TypeIDPosition(s)Description
Binding site531ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionligase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      JVX33_01095

Organism names

Accessions

  • Primary accession
    A0AAJ1BLL0

Proteomes

Subcellular Location

Cytoplasm

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, motif, coiled coil.

TypeIDPosition(s)Description
Domain19-568Aminoacyl-tRNA synthetase class Ia
Motif47-57'HIGH' region
Motif528-532'KMSKS' region
Domain611-757Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Coiled coil815-884
Domain817-882Valyl-tRNA synthetase tRNA-binding arm

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    884
  • Mass (Da)
    102,228
  • Last updated
    2024-07-24 v1
  • Checksum
    5C2A6533084CD74B
MTEKDMSTKYDPAAVEEGRYQWWIDQGFFKPSGDKKAHPYSIVIPPPNVTGKLHLGHAWDTTLQDMIIRQKRMQGYDVLWVPGMDHAGIATQAKVEARLRKQGISRYDLGRDKFVQQVWDWKDEYADIIHQQWAKMGISVDYDRERFTLDEGLNKAVRKVFVDLYNKGLIYRGTYIINWDPQARTALSDIEVIHKDDKGAFYHVKYPFTDGTTFNGKDYIEIATTRPETMFGDEAVAVNPNDERYKDLVGKKVMVPLVNREIEIIADDYVTPEFGTGMVKITPAHDPNDFKVGKRHNLPELNTMNEDATMNENAGKYEGMDRFEAREAIVKDLQDQGYMLKVDPIVHSVGHSERTGVQVEARLSTQWFVKMKPLAEAALKNQDTDDRVNFVPERFEHTFTQWMENIHDWVISRQLWWGHRIPAWYNKQTGEVYVGMEAPKDAENWEQDKDVLDTWFSSALWPFSTMGWPNTDSADFKRYFPTNTLVTGYDIIFFWVSRMIFQSLEFTGRAPFKNVLLHGLIRDEQGRKMSKSLGNGIDPMDVIKKYGVDALRWFLITGSTPGQDIRFSYTKMDAAWNFINKIWNASRYVIMNLGEMPAPVLPDKSKWDLADRWILSRLNATVKQVNEQFDKFEFGEAGRALYNFIWNDFCDWYIEMTKEKLNNGTDEEKNDTKNILGYVLDQTLKMLHPIMPFVTEKLWQSMPHDGESIMVADYPVANAELDDPAATEQMNSLIELIKAVRNIRNEANAPMSKPVDILVKVDSDHLAQMLNDNRDYIERFCHPENLTIGKDVEAPKLAMSGILTGAEVYIPMAELVDLDEERDRMEKEIAKLEKEVERSQKKLGNEKFVNNAPEKVVEAERQKATEWQQKLAAAKERLQSLQQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFFPO010000001
EMBL· GenBank· DDBJ
MCH5356904.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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