A0AAI9X036 · A0AAI9X036_9ASCO

  • Protein
    Kynureninase
  • Gene
    BNA5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site115pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site116pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site143-146pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site231pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site234pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site256pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site291pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site319pyridoxal 5'-phosphate (UniProtKB | ChEBI)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynureninase
  • EC number
  • Alternative names
    • Biosynthesis of nicotinic acid protein 5
    • L-kynurenine hydrolase

Gene names

    • Name
      BNA5
    • ORF names
      KGF56_000454

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 10844
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida

Accessions

  • Primary accession
    A0AAI9X036

Proteomes

Subcellular Location

Cytoplasm

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue257N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the kynureninase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    472
  • Mass (Da)
    53,749
  • Last updated
    2024-07-24 v1
  • Checksum
    2360FE88183100C6
MSLEDAKQLDKRFPTYKHEFNVPTFESLGINNSQFPPTTESIYLCGNSLGLMPKQTSKAINNELQAWSMRGVEAHFNHPGEPKLTNWVDIDLPILPMLSQIVGANQNEVAVMGSLTSNLNALLIHFYKPLGKRTKILFEKQAFPSDYYAFLNIVKLFGFDESHLIQIEVQAGETYLKTEQIIDAIDKNFPELALVCLPGIQYYTGQYFEIEKITKYIKSKSGDENIPVGWDLAHAVGNVPLQLHSWGVDFAAWCSYKYLNSGPGAIAGIFVHEKHTAQNTSDSYKPRLAGWWGNNSKERFKMIEKFDPIASALSYRQSNPSVIDCVALHSSLQVFDKAGGMQPLREKSIVLTQFLQEILVKSKYYIKQSDLDQTKFGFKILTPLDPMQRGCQLSLLFQPHKENKDENVMENVFKYLHQYAIICDERRPDVIRIAPLPLYNTFEETYRAAKRLLEALDKFAIVNNNNNNNNNT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHUZD010000021
EMBL· GenBank· DDBJ
KAI3406848.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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