A0AAI9SYY1 · A0AAI9SYY1_9ASCO

  • Protein
    Acyl-coenzyme A diphosphatase SCS3
  • Gene
    SCS3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site950
Active site1035

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-coenzyme A diphosphatase SCS3
  • EC number
  • Alternative names
    • FIT family protein SCS3

Gene names

    • Name
      SCS3
    • Synonyms
      FIT2B
    • ORF names
      KGF56_001512

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 10844
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida

Accessions

  • Primary accession
    A0AAI9SYY1

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-40Helical
Transmembrane47-67Helical
Transmembrane87-110Helical
Transmembrane122-146Helical
Transmembrane161-180Helical
Transmembrane766-786Helical
Transmembrane811-831Helical
Transmembrane843-866Helical
Transmembrane1011-1034Helical
Transmembrane1041-1061Helical

Keywords

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, domain.

TypeIDPosition(s)Description
Compositional bias258-299Basic and acidic residues
Region258-330Disordered
Compositional bias300-314Polar residues
Coiled coil365-397
Domain592-679BioF2-like acetyltransferase

Sequence similarities

Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,065
  • Mass (Da)
    122,767
  • Last updated
    2024-07-24 v1
  • Checksum
    81AEF50028982D30
MHLNQQDLLLVHLSDGQRIGYLVISLINLLCNCAVLSIWWSTSISSVYLLFASINVIEILISISIIQINLDLINISFDRPAKKMHNLFVLCGAFMIGQSIMGISIVVLINEKNRLSEIIGRLIFTYDVLSFCLGLLYVACTAVASVKFDYKPMDGLNEIPISLPILFGITVGILMIEIGCSRYFRIRTLQTLYEVEEYDLCGLTEHQKQGWSKLINLNRKYNAGISGENVISLMENYLHAELPGMKCKVLRVFNKNEKHEKVGEQSENQREQQKQQQQHKQQKQQHNKKEKEINENHLEKLQTESTLASNQPGSHEKKQSHHKKAMHTAFEQLDQESFLFSNAPTLNDANTSIQYLEDEYKPLSKNQLKKLAKKSKQAKQQKELASLENNTEKFYQELMNTQALVLLTIVEEFDLTERIPGWVGKKLNKLFGRNSRWPILCIKFGLLGFHWPFKRSTFYCSATKKPIARSASILYAISHWNKVHEKCAVLLDPGYKDASFEAGVDYSGWIKIKLPNSHIIDLRPFHNQTSTEYFKAIKYRNQDNAFKQSQGQVIESYNFNFENCQEIIAMNDNIAQNRQQNGQSSQLLHPDWEFIYNLGNFANDQKYRSLLFLKVGDKIIASCVIFRLGETMTSDIQGLDHEISKKYKAYFVMMQEVIKMGLRENVSFIDFGPTTEEAKVAIGCSVVPLIGSIYPRHKFMGPIIRFAASKVDGIICWLYSQRFPDFSMSFSGTSREPDAIYDTHYAKFKSICHSLYTNYRITMNELLIISLYILNFVLSRLIHFGAPEEEVYNYFNNKGNFLNYFFVKRGWGWTTLVIMFYYFGHVFRYLIESNKKKSNDKEAKIGTVIGGAILRYGLATIWWYLFTQWCFGLPIMDKVFIFTGGACHLEPVSSSSSSGTIPPLREKHTNIAKHFVQDIETMIWKSSSVTSRNCRQVNGSWIGGHDPSGHVFLMIHSSLYLYFESARFFNWKSLVQTACYFVDKIKAKNNKNNNKRIDVRVEDTARLIGDLAQLSIVFLIALWWFMLLMTNVYFHSILEKLVGLMFGYVGIFVIYFIPRWINIGV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias258-299Basic and acidic residues
Compositional bias300-314Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHUZD010000028
EMBL· GenBank· DDBJ
KAI3405494.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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