A0AAI9BF89 · A0AAI9BF89_ENTFC
- ProteinMultifunctional fusion protein
- GenepyrE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids450 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- H+ + orotidine 5'-phosphate = CO2 + UMP
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13 | substrate | ||||
Sequence: D | ||||||
Binding site | 36 | substrate | ||||
Sequence: K | ||||||
Binding site | 63-72 | substrate | ||||
Sequence: DLKLHDIPNT | ||||||
Active site | 65 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 126 | substrate | ||||
Sequence: T | ||||||
Binding site | 188 | substrate | ||||
Sequence: R | ||||||
Binding site | 197 | substrate | ||||
Sequence: Q | ||||||
Binding site | 217 | substrate | ||||
Sequence: G | ||||||
Binding site | 218 | substrate | ||||
Sequence: R | ||||||
Binding site | 337 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 341 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: K | ||||||
Binding site | 343 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: H | ||||||
Binding site | 363-371 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: EDLISTGGS | ||||||
Binding site | 367 | orotate (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glycosyltransferase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT ; OPRTase
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Enterococcus
Accessions
- Primary accessionA0AAI9BF89
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-233 | Orotidine 5'-phosphate decarboxylase | ||||
Sequence: RPIIALDFSTWQEVEDFLLFFPEEEKLFVKIGMELFYQEGPEIVRYLKDAGHDVFLDLKLHDIPNTVEKAMRGLAKLGVDVTCVHAAGGIRMMEAAMRGLEEGTPEGGKRPLLLAITQLTSTSEEEMHADQLIEVPLEKSVIHYANCAKKAGLDGVVSSAWEVEAIKETAGDEFVCLTPGIRPEGTVVGDQTRVVTPSQAREIGSTFIVVGRPITQATDPYEAYRAI |
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
In the C-terminal section; belongs to the OMP decarboxylase family.
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length450
- Mass (Da)49,859
- Last updated2024-07-24 v1
- ChecksumC27577ACE655D9F6