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A0AAI8SMS9 · A0AAI8SMS9_MYCAV

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

Type
IDPosition(s)Description
Site110Transition state stabilizer
Active site114Proton acceptor
Binding site279Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG2
    • Synonyms
      katG
    • ORF names
      JPH1_26170
      , QRB41_16510

Organism names

  • Taxonomic identifier
  • Strains
    • JP-H-1
    • FLAC0813
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium avium complex (MAC)

Accessions

  • Primary accession
    A0AAI8SMS9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link238↔264Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-113)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-43Disordered
Domain147-424Plant heme peroxidase family profile

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    748
  • Mass (Da)
    81,675
  • Last updated
    2024-07-24 v1
  • MD5 Checksum
    7DC15C21F80BE9E4073063F1DB4397E0
MSSDTSASRPPQPDTGTASKSESENPAIPSPHPKSNAPLTNRDWWPNQIDVSRLHPHVAEANPLGEDFDYAEEFAKLDVEALKADVISVMTTSQDWWPADYGHYGGLFIRMSWHAAGTYRIHDGRGGGGQGMQRFAPLNSWPDNVSLDKARRLLWPVKKKYGNKISWADLIIFAGNCALESMGFKTFGFAFGREDVWEPEEILWGEEDEWLGTDKRYPGTGERELAQPYGATTMGLIYVNPEGPEGKPDPIAAAIDIRETFGRMAMNDEETAALIVGGHSFGKTHGAGDADLVGPEPEAAPIEQQGLGWKSSYGTGVGKDAITSGLEVVWTPTPTKWDNTFLETLYGYEWELTKSPAGAWQFTAKDGAGAGTIPDPFGGPGRAPTMLVTDISLRESPIYRDITRRWLDHPEELADAFAKAWYKLLHRDMGPVSRFLGPWVPEPQLWQDPVPPVDHPLVDDNDVAALKDKVLASGLSVPQLVKTAWSAAGSYRNTDKRGGANGGRLRLQPQRNWEANEPSELDKVLPVLEKIQQDFNASASGGKKISLADLIVLAGSAAVEKAAKDAGYEISVHFAPGRTDASQESTDVDSFAVLEPRADGFRNFARPGEKAPLEQLLLERAYLLGLTGPEMTVLVGGLRALGANHGGSKHGVFTDRPGALTNDFFVNLLDMGTEWKASETAENVYEGHDRATGALKWTATANDLVFGSNSVLRALAEVYAQDDNQGKFVEDFVAAWVKVMNNDRFDLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP020326
EMBL· GenBank· DDBJ
BBN48142.1
EMBL· GenBank· DDBJ
Genomic DNA
JAULCP010000017
EMBL· GenBank· DDBJ
MDO2384973.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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