A0AAI8MH78 · A0AAI8MH78_9BRAD

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48NADP+ (UniProtKB | ChEBI)
Binding site54NADP+ (UniProtKB | ChEBI)
Binding site131-133FMN (UniProtKB | ChEBI)
Binding site243-244FMN (UniProtKB | ChEBI)
Binding site287FMN (UniProtKB | ChEBI)
Binding site302-306FMN (UniProtKB | ChEBI)
Binding site328FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionchorismate synthase activity
Molecular FunctionFMN binding
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • ORF names
      S23_53330

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S23321
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Bradyrhizobium

Accessions

  • Primary accession
    A0AAI8MH78

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    38,907
  • Last updated
    2024-07-24 v1
  • Checksum
    BEFA5F566DFF5E6D
MSFNTFGHMFRVTTFGESHGVAIGCVVDGCPPMIPLTEADIQQDLDRRRPGQSRFTTQRQEPDQVKILSGVMAHPETGVQVTTGTPIGLLIENTDQRSKDYSEIKDKFRPGHADFTYEAKYGLRDYRGGGRSSARETATRVAAGAIARKVLPDVKVRGALVQMGPHKIDRDKWDWDEIAKNPFFCPDKDKAAFFETYLDGIRKSGSSIGAVLEIVAEGVPAGLGAPIYAKLDSDLAGAMMTINAVKGVEIGAGFGAAELTGEENADEMRTGNDGTRFLSNHAGGILGGISTGQPVVVRFAVKPTSSILQPRRTVDRQGADTEIFTKGRHDPCVGIRAVPVGEAMMACVLADHFLRDRGQVG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012279
EMBL· GenBank· DDBJ
BAL78526.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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