A0AAI8MBQ8 · A0AAI8MBQ8_9BRAD

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site117-119substrate
Binding site148-151substrate; in site B
Binding site158-160substrate
Binding site206substrate
Active site207Proton donor/acceptor
Active site337
Binding site338substrate
Binding site343-345substrate
Site350Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      S23_18170

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S23321
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Bradyrhizobium

Accessions

  • Primary accession
    A0AAI8MBQ8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Domain31-361Fumarate lyase N-terminal
Domain427-480Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    482
  • Mass (Da)
    51,935
  • Last updated
    2024-07-24 v1
  • Checksum
    F2101F2153273625
MDVLMAKAARSKPTNSKTARPATRIETDSFGPIEVPADRYWGAQTERSRQNFRIGIDRMPISLVHALGIVKLAAAQSNLELGLLDQRRANAIIRAAREVIEGKLDDHFPLVVWQTGSGTQSNMNLNEVIANRANELLGGELGAKKPVHPNDHVNMSQSSNDSFPTAMHIAAANRINADLVPALGELLRALRKKEKEFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVESGIARLKVAVKELYPLAQGGTAVGTGLNSSPRFAKLFAKHAAGITKLPFTSAANKFEALASNDAYVLAHGAINSVATGLFKIANDIRLLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVCCQVFGNHTAITVAGSQGHFELNVYKPVLAYNMLHSIRLMADAARSFTEHCVSGIRADEKRIKELMQRSLMLVTALAPKIGYDNAAKVAKTAHANGTTLKEEALRLGLVSAEEFDRLVQPEKMTRPG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012279
EMBL· GenBank· DDBJ
BAL75033.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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