A0AAI8HS75 · A0AAI8HS75_9BACI
- ProteinProtein-arginine kinase
- GenemcsB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
Catalytic activity
- L-arginyl-[protein] + ATP = N(omega)-phospho-L-arginyl-[protein] + ADP + H+
Activity regulation
Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 27-31 | ATP (UniProtKB | ChEBI) | |||
Binding site | 92 | ATP (UniProtKB | ChEBI) | |||
Binding site | 125 | ATP (UniProtKB | ChEBI) | |||
Binding site | 176-180 | ATP (UniProtKB | ChEBI) | |||
Binding site | 207-212 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | creatine kinase activity | |
Molecular Function | protein kinase activity | |
Biological Process | phosphocreatine biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein-arginine kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus amyloliquefaciens group
Accessions
- Primary accessionA0AAI8HS75
Proteomes
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 24-254 | Phosphagen kinase C-terminal | |||
Motif | 337-342 | RDXXRA motif of the pArg binding pocket involved in allosteric regulation | |||
Sequence similarities
Belongs to the ATP:guanido phosphotransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length363
- Mass (Da)40,984
- Last updated2024-07-24 v1
- Checksum985C5696223CA8BD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP025001 EMBL· GenBank· DDBJ | AUJ79163.1 EMBL· GenBank· DDBJ | Genomic DNA |