A0AAI8EZY0 · A0AAI8EZY0_HELP1

Function

function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site244NAD+ (UniProtKB | ChEBI)
Binding site293-295NAD+ (UniProtKB | ChEBI)
Binding site295K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site297K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site298IMP (UniProtKB | ChEBI)
Active site300Thioimidate intermediate
Binding site300K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site333-335IMP (UniProtKB | ChEBI)
Binding site356-357IMP (UniProtKB | ChEBI)
Binding site380-384IMP (UniProtKB | ChEBI)
Active site396Proton acceptor
Binding site410IMP (UniProtKB | ChEBI)
Binding site464K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site465K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site466K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine-5'-monophosphate dehydrogenase
  • EC number
  • Short names
    IMP dehydrogenase
    ; IMPD
    ; IMPDH

Gene names

    • Name
      guaB
    • Ordered locus names
      KHP_0498

Organism names

  • Taxonomic identifier
  • Strain
    • 51
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    A0AAI8EZY0

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain92-148CBS
Domain152-209CBS

Sequence similarities

Belongs to the IMPDH/GMPR family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    51,830
  • Last updated
    2024-07-24 v1
  • Checksum
    0A87308D3530A7F1
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHVHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDALVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYYG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000012
EMBL· GenBank· DDBJ
ACX97706.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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