A0AAI8DGN9 · A0AAI8DGN9_MAMSC

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site42-443-dehydroquinate (UniProtKB | ChEBI)
Binding site773-dehydroquinate (UniProtKB | ChEBI)
Active site138Proton donor/acceptor
Active site165Schiff-base intermediate with substrate
Binding site2073-dehydroquinate (UniProtKB | ChEBI)
Binding site2303-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • ORF names
      CEP64_09240

Organism names

Accessions

  • Primary accession
    A0AAI8DGN9

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    27,809
  • Last updated
    2024-07-24 v1
  • Checksum
    9418BC0C38A3A887
MTDGQKKAFPYIVATISLETQDDIEKTVQELNAHKDSIDIVEFRADTLKNTSIENINETLEQFKSAYHDAPILFTYRSVGQGGHGDFDHETYYKIMQDIICNKKAEYVDIQLDTYEDNLMNCITKAQHNDVKIIISHHDFKSTPDVEEMFVTYEKMAELGANIGKLAVMPQNERHLLSMLNAMNRAYHKLDIDVIGISMGELGKMTRITGGMFGSKFTYGFVGKEAAPGQIHVKDIKEQLALYQN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP022046
EMBL· GenBank· DDBJ
ASE34767.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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