A0AAG2UWZ2 · A0AAG2UWZ2_HUMAN
- ProteinPTPRF interacting protein alpha 1
- GenePPFIA1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1242 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionA0AAG2UWZ2
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,027 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 77 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 150 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 230 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 238 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 239 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 242 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 244 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 448 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 530 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 546 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 572 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 601 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 666 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 668 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 680 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 692 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 693 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 697 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 700 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 708 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 750 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 751 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 754 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 755 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 771 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 773 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 783 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 784 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 786 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 799 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 800 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 803 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1196 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1199 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1211 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1212 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1214 | PRIDE | Phosphoserine | ||||
Sequence: S |
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-33 | Disordered | ||||
Sequence: MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDAD | ||||||
Coiled coil | 97-131 | |||||
Sequence: LNVCREQLLEREEEIAELKAERNNTRLLLEHLECL | ||||||
Compositional bias | 224-239 | Polar residues | ||||
Sequence: NHEQENTPSTSGKRSS | ||||||
Region | 224-245 | Disordered | ||||
Sequence: NHEQENTPSTSGKRSSDGSLSH | ||||||
Region | 426-446 | Disordered | ||||
Sequence: KNQELQRARQREKMNEEHNKR | ||||||
Coiled coil | 469-517 | |||||
Sequence: RMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLR | ||||||
Region | 651-865 | Disordered | ||||
Sequence: ENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLPSDLRKHRRKLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKN | ||||||
Compositional bias | 681-699 | Polar residues | ||||
Sequence: IPPYPASSLASSSPPGSGR | ||||||
Compositional bias | 721-747 | Basic and acidic residues | ||||
Sequence: LPSDLRKHRRKLPPSREEVRDDKTTIK | ||||||
Compositional bias | 759-782 | Basic and acidic residues | ||||
Sequence: LRLDRLHKGALHTVSHEDIRDIRN | ||||||
Compositional bias | 783-803 | Polar residues | ||||
Sequence: STGSQDGPVSNPSSSNSSQDS | ||||||
Compositional bias | 841-855 | Polar residues | ||||
Sequence: GVSETDNSSQDALGL | ||||||
Domain | 888-954 | SAM | ||||
Sequence: WDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSL | ||||||
Domain | 1010-1067 | SAM | ||||
Sequence: EWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRL | ||||||
Domain | 1091-1160 | SAM | ||||
Sequence: WSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVM | ||||||
Region | 1203-1242 | Disordered | ||||
Sequence: NFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTYSC |
Sequence similarities
Belongs to the liprin family. Liprin-alpha subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,242
- Mass (Da)140,398
- Last updated2024-07-24 v1
- Checksum7CA9E571E1B8DCC1
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13136 | LIPA1_HUMAN | PPFIA1 | 1202 | ||
A0A2R8Y7R9 | A0A2R8Y7R9_HUMAN | PPFIA1 | 1224 | ||
A0AAG2UY63 | A0AAG2UY63_HUMAN | PPFIA1 | 99 | ||
A0AAG2UWS2 | A0AAG2UWS2_HUMAN | PPFIA1 | 237 | ||
A0AAG2UWZ6 | A0AAG2UWZ6_HUMAN | PPFIA1 | 253 | ||
A0AAG2UWH4 | A0AAG2UWH4_HUMAN | PPFIA1 | 158 | ||
A0AAG2UWI0 | A0AAG2UWI0_HUMAN | PPFIA1 | 389 | ||
A0AAG2UWJ5 | A0AAG2UWJ5_HUMAN | PPFIA1 | 386 | ||
H0YEF9 | H0YEF9_HUMAN | PPFIA1 | 387 | ||
H0YDZ8 | H0YDZ8_HUMAN | PPFIA1 | 253 | ||
H0YF15 | H0YF15_HUMAN | PPFIA1 | 97 | ||
H0YEK0 | H0YEK0_HUMAN | PPFIA1 | 46 | ||
H0YD72 | H0YD72_HUMAN | PPFIA1 | 237 | ||
H0YDW2 | H0YDW2_HUMAN | PPFIA1 | 389 | ||
H0YD39 | H0YD39_HUMAN | PPFIA1 | 33 | ||
A0A1B0GVT3 | A0A1B0GVT3_HUMAN | PPFIA1 | 271 | ||
E9PPF6 | E9PPF6_HUMAN | PPFIA1 | 158 | ||
E9PJZ7 | E9PJZ7_HUMAN | PPFIA1 | 583 | ||
E9PID5 | E9PID5_HUMAN | PPFIA1 | 99 | ||
A0A3B3ITS2 | A0A3B3ITS2_HUMAN | PPFIA1 | 166 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 224-239 | Polar residues | ||||
Sequence: NHEQENTPSTSGKRSS | ||||||
Compositional bias | 681-699 | Polar residues | ||||
Sequence: IPPYPASSLASSSPPGSGR | ||||||
Compositional bias | 721-747 | Basic and acidic residues | ||||
Sequence: LPSDLRKHRRKLPPSREEVRDDKTTIK | ||||||
Compositional bias | 759-782 | Basic and acidic residues | ||||
Sequence: LRLDRLHKGALHTVSHEDIRDIRN | ||||||
Compositional bias | 783-803 | Polar residues | ||||
Sequence: STGSQDGPVSNPSSSNSSQDS | ||||||
Compositional bias | 841-855 | Polar residues | ||||
Sequence: GVSETDNSSQDALGL |
Keywords
- Technical term