A0AAF0T7S8 · A0AAF0T7S8_9EURY

Function

function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Catalytic activity

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site241L-serine (UniProtKB | ChEBI)
Binding site241-243L-serine (UniProtKB | ChEBI)
Binding site272L-serine (UniProtKB | ChEBI)
Binding site272-274ATP (UniProtKB | ChEBI)
Binding site288ATP (UniProtKB | ChEBI)
Binding site288-291ATP (UniProtKB | ChEBI)
Binding site295L-serine (UniProtKB | ChEBI)
Binding site368-371ATP (UniProtKB | ChEBI)
Binding site402L-serine (UniProtKB | ChEBI)
Binding site404L-serine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionserine-tRNA ligase activity
Biological Processselenocysteine biosynthetic process
Biological Processseryl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine--tRNA ligase
  • EC number
  • Alternative names
    • Seryl-tRNA synthetase
      (SerRS
      )
    • Seryl-tRNA(Ser/Sec) synthetase

Gene names

    • Name
      serS
    • ORF names
      NP511_08930

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A29
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natrinema

Accessions

  • Primary accession
    A0AAF0T7S8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The tRNA molecule binds across the dimer.

Family & Domains

Features

Showing features for region, coiled coil, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Coiled coil63-104
Domain138-429Aminoacyl-transfer RNA synthetases class-II family profile

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    52,438
  • Last updated
    2024-05-29 v1
  • Checksum
    97F2C1D3229C7FCC
MLDRTDLRENPDEVRSALDDRGADVDIDELLELDERWRELKARGDDLRHERNQITKKIGQLVADGEDEKREEAIERSQDLKAEIEDVEDEAIELQDELQERLLEVPQLPDESVPLGVDERHNVEDRRWGFDEDHDLPDEVTPHYELGEELDIIDEERAAKTTGAGFYFLKGEGAQLEHALIQFMMDVHREQGYVDVFPPVPVKSSSMQGTGQLPKFADDAYRLGGNNEEAYDDDDLWLCPTAEVPVTNMYADEILLDDDLPLKHQAYTPNFRREAGEHGTETRGIVRVHQFNKVELVNFVEPEDSYDRLEDLLDEAEEVLRRLDLPYRILELCTGDLTFASAKTYDIEVWAPGDDMDDGPEEGGRWLEVSSASNFEDFQARRAGLRYRPERHESAEYLHTLNASGLAIPRVMVAILEYYQNEDGTVTIPEPLRPYMGGKEVIEGHEKVGESALGAGERE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP101873
EMBL· GenBank· DDBJ
WMT09739.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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