A0AAF0GYM6 · A0AAF0GYM6_RHIRD

Function

function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site29-30D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site30Mg2+ 2 (UniProtKB | ChEBI)
Binding site30Mg2+ 1 (UniProtKB | ChEBI)
Binding site34D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site128Essential for catalytic activity
Binding site142-146D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site145Mg2+ 2 (UniProtKB | ChEBI)
Site166Essential for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3,4-dihydroxy-2-butanone 4-phosphate synthase
  • EC number
  • Short names
    DHBP synthase

Gene names

    • Name
      ribB
    • ORF names
      CFBP5506_01915

Organism names

Accessions

  • Primary accession
    A0AAF0GYM6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain213-361GTP cyclohydrolase II

Sequence similarities

Belongs to the DHBP synthase family.
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
In the N-terminal section; belongs to the DHBP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    40,183
  • Last updated
    2024-05-29 v1
  • Checksum
    C8E0033CCB2F07AF
MAYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTAEKMALIVRHTSGIVCAPMPREEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGASDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPPIGVICELVNDDGTVMRGPQVLDFAEKHGMKYVSVADLIAYRQRKETLVEMETSFTIDTPFGPAKAQTYSLPWDPMQHMAVIFGDIRDGVDIPVRLHPENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVAGRRKARDPEEAHAQARSRENEWLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIKISATDIC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP122962
EMBL· GenBank· DDBJ
WGM59637.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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